ReviewEnvironmental science and pollution research international2014
Anogenital distance and its application in environmental health research.
Review in Environmental science and pollution research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Phthalate exposure and male reproductive outcomes: A systematic review of the human epidemiological evidence.Environment international · 2018Pooled it
- Gestational benzyl butyl phthalate exposure impairs sperm capacitation in F1 offspring by altering PKA-associated signaling and tyrosine phosphorylation.Archives of toxicology · 2026Article
- Associations of glyphosate and aminomethylphosphonic acid (AMPA) concentrations with birth outcomes in pregnant women from the Midwestern U.S.International journal of hygiene and environmental health · 2026Article
- Article
- Association between prenatal phthalate exposure and ano-genital indices among offsprings in an Israeli cohort.Heliyon · 2024Article
- Association of prenatal chlorpyrifos exposure with sexually dimorphic differences in anogenital distance among Thai farmworker children.Environmental research · 2024Article
- Association between anogenital distance as a noninvasive index in the diagnosis and prognosis of reproductive disorder: A systematic review.International journal of reproductive biomedicine · 2023Review
- Associations of maternal anthropometrics with newborn anogenital distance and the 2:4 digit ratio.Human reproduction (Oxford, England) · 2022Article
- Sex-specific ranges and ratios for anogenital distance among Thai full-term newborns.BMC pediatrics · 2022Article
- Prenatal exposure to a low dose of BPS causes sex-dependent alterations to vascular endothelial function in adult offspring.Frontiers in toxicology · 2022Article
- Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture.Nutrients · 2021Review
- Molecular and Cytogenetic Analysis of Romanian Patients with Differences in Sex Development.Diagnostics (Basel, Switzerland) · 2021Article
- 46,XX DSD: Developmental, Clinical and Genetic Aspects.Diagnostics (Basel, Switzerland) · 2021Review
- Maternal organophosphate flame-retardant exposure alters offspring feeding, locomotor and exploratory behaviors in a sexually-dimorphic manner in mice.Journal of applied toxicology : JAT · 2021Article
- Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population.Human reproduction (Oxford, England) · 2019Article
- Anogenital distance as a phenotypic signature through infancy.Pediatric research · 2018Article
- Thyroid Hormone Status in Umbilical Cord Serum Is Positively Associated with Male Anogenital Distance.The Journal of clinical endocrinology and metabolism · 2016Article
- Anogenital distance as a marker of androgen exposure in humans.Andrology · 2016Review
- Do endocrine disruptors cause hypospadias?Translational andrology and urology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anogenital distance (AGD), a useful anthropometric measurement for genital development in both animals and humans, was originally found by reproductive toxicologists in rodent experiments. As an easy-to-measure and sensitive marker, AGD has become a bioassay of fetal androgen action and a well-established reproductive toxicity endpoint in animals. It is generally accepted that AGD is sexually dimorphic in many mammals, with males having longer AGD than females. Exposure to proposed endocrine disruptors may result in reduced AGD; thus, it has been used to measure health effects of compounds with endocrine-altering properties or endocrine-disrupting chemicals (EDCs) in environmental toxicology. Moreover, AGD is an important clinical measure to address endocrine-sensitive endpoints in the first year of life and to assess the adverse impact of in utero exposure to environmental EDCs. Recently, AGD has been identified as one of the endpoints in the US Environmental Protection Agency guidelines for reproductive toxicity studies in humans, but use of AGD in human studies is still rare, and the results remain mixed and inconclusive due to many reasons. In order to achieve a breakthrough, researchers are endeavoring to standardize the measurement of AGD, normalize age-specific population data in different ethnic groups, and conduct more in-depth human researches in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.