ReviewJournal of mammary gland biology and neoplasia2014
Colostrogenesis: IgG1 transcytosis mechanisms.
Review in Journal of mammary gland biology and neoplasia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 92 citations in OpenAlex.
- High-Starch Diet Prepartum Enhances IgG Concentration in Goat Colostrum Without Affecting the Transfer of Passive Immunity.Journal of animal physiology and animal nutrition · 2026Article
- Effects of Prepartum Supplementation and Yeast Fermentation Products on the Progesterone-Modulated Transfer of Passive Immunity in Bos indicus Cows.Journal of animal physiology and animal nutrition · 2026Article
- Expression of ultralong complementarity determining region 3 and development of IgM and IgG B cell receptor repertoires in Holstein heifer calves.ImmunoHorizons · 2026Article
- Perinatal physiology and welfare in water buffalo: calving, mother-calf bonding, lactation, and postpartum disorders.Frontiers in veterinary science · 2026Review
- A retrospective cohort study investigating the association of environment, milk performance and udder health with the yield and solid content of first-milking colostrum in Holstein dairy cows.BMC veterinary research · 2025Article
- Deciphering the colostral-immunity transfer: from mammary gland to neonates small intestine.Veterinary research communications · 2025Review
- Evaluating the inoculating bacterial communities within the bovine neonatal respiratory tract after applying an ablation technique to the dam vaginal microbiota prior to parturition.Journal of animal science · 2025Article
- Association between subclinical mastitis pathogens and passive transfer of immunity in calves.Frontiers in veterinary science · 2025Article
- Bovine Colostrum in Pediatric Nutrition and Health.Nutrients · 2024Review
- Investigating the IgM and IgG B Cell Receptor Repertoires and Expression of Ultralong Complementarity Determining Region 3 in Colostrum and Blood from Holstein-Friesian Cows at Calving.Animals : an open access journal from MDPI · 2024Article
- Selective IgG binding to the LPS glycolipid core found in bovine colostrum, or milk, duringInnate immunity · 2024Article
- A Comprehensive Review of Bovine Colostrum Components and Selected Aspects Regarding Their Impact on Neonatal Calf Physiology.Animals : an open access journal from MDPI · 2024Review
- The importance of colostrum in maternal care and its formation in mammalian species.Animal frontiers : the review magazine of animal agriculture · 2023Article
- Chemometric Approaches to Analyse the Composition of a Ewe's Colostrum.Animals : an open access journal from MDPI · 2023Article
- Adaptive Cell-Mediated Immunity in the Mammary Gland of Dairy Ruminants.Frontiers in veterinary science · 2022Review
- Colostrogenesis: Role and Mechanism of the Bovine Fc Receptor of the Neonate (FcRn).Journal of mammary gland biology and neoplasia · 2021Review
- Supplementing lycopene combined with corn improves circulating IgG concentration in pregnant ewes and their lambs.Tropical animal health and production · 2021Article
- The Specific Immune Response after Vaccination against Neonatal Calf Diarrhoea Differs between Apparent Similar Vaccines in a Case Study.Animals : an open access journal from MDPI · 2021Article
- Bovine Colostrum and Its Potential for Human Health and Nutrition.Frontiers in nutrition · 2021Review
- Structural features of bovine colostral immunoglobulin that confer proteolytic stability in a simulated intestinal fluid.The Journal of biological chemistry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological transport of intact proteins across epithelial cells has been documented for many absorptive and secretory tissues. Immunoglobulins were some of the earliest studied proteins in this category. The transcellular transport (transcytosis) of immunoglobulins in neonatal health and development has been recognized; the process is especially significant with ungulates because they do not transcytose immunoglobulins across the placenta to the neonate. Rather, they depend upon mammary secretion of colostrum and intestinal absorption of immunoglobulins in order to provide intestinal and systemic defense until the young ungulate develops its own humoral defense mechanisms. The neonatal dairy calf's ability to absorb immunoglobulins from colostrum is assisted by a ~24 h "open gut" phenomenon where large proteins pass the intestinal epithelial cells and enter the systemic system. However, a critical problem recognized for newborn dairy calves is that an optimum mass of colostrum Immunoglobulin G (IgG) needs to be absorbed within that 24 h window in order to provide maximal resistance to disease. Many calves do not achieve the optimum because of poor quality colostrum. While many studies have focused on calf absorption, the principal cause of the problem resides with the extreme variation (g to kg) in the mammary gland's capacity to transfer blood IgG1 into colostrum. Colostrum is a unique mammary secretory product that is formed during late pregnancy when mammary cells are proliferating and differentiating in preparation for lactation. In addition to the transcytosis of immunoglobulins, the mammary gland also concentrates a number of circulating hormones into colostrum. Remarkably, the mechanisms in the formation of colostrum in ungulates have been rather modestly studied. The mechanisms and causes of this variation in mammary gland transcytosis of IgG1 are examined, evaluated, and in some cases, explained.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.