ArticleProtein & cell2014
Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes.
Article in Protein & cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- Article
- Stage-specific DNA methylation dynamics in mammalian heart development.Epigenomics · 2025Review
- Epigenetic Regulation of Mammalian Cardiomyocyte Development.Epigenomes · 2024Review
- DNA methylome and transcriptome profiling reveal key electrophysiology and immune dysregulation in hypertrophic cardiomyopathy.Epigenetics · 2023Article
- Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging.Protein & cell · 2023Article
- Beyond AOPs: A Mechanistic Evaluation of NAMs in DART Testing.Frontiers in toxicology · 2022Article
- 4-phenylbutyrate exerts stage-specific effects on cardiac differentiation via HDAC inhibition.PloS one · 2021Article
- Epigenetic Regulation of Cardiac Development and Disease through DNA Methylation.Journal of life sciences (Westlake Village, Calif.) · 2019Article
- Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity.Stem cells international · 2018Article
- Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.Nucleic acids research · 2017Article
- Mapping Human Pluripotent-to-Cardiomyocyte Differentiation: Methylomes, Transcriptomes, and Exon DNA Methylation "Memories".EBioMedicine · 2016Article
- DNA Methylation Dynamics Regulate the Formation of a Regenerative Wound Epithelium during Axolotl Limb Regeneration.PloS one · 2015Article
- Discrete Logic Modelling Optimization to Contextualize Prior Knowledge Networks Using PRUNET.PloS one · 2015Article
- Epigenetic regulation of pluripotency and differentiation.Circulation research · 2014Review
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 4 countries.
Funding
Abstract
With defined culture protocol, human embryonic stem cells (hESCs) are able to generate cardiomyocytes in vitro, therefore providing a great model for human heart development, and holding great potential for cardiac disease therapies. In this study, we successfully generated a highly pure population of human cardiomyocytes (hCMs) (>95% cTnT(+)) from hESC line, which enabled us to identify and characterize an hCM-specific signature, at both the gene expression and DNA methylation levels. Gene functional association network and gene-disease network analyses of these hCM-enriched genes provide new insights into the mechanisms of hCM transcriptional regulation, and stand as an informative and rich resource for investigating cardiac gene functions and disease mechanisms. Moreover, we show that cardiac-structural genes and cardiac-transcription factors have distinct epigenetic mechanisms to regulate their gene expression, providing a better understanding of how the epigenetic machinery coordinates to regulate gene expression in different cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.