ArticleG3 (Bethesda, Md.)2014
Yeast growth plasticity is regulated by environment-specific multi-QTL interactions.
Article in G3 (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Rethinking yield stability through phenotypic plasticity and its link to modern statistical methods.Journal of experimental botany · 2026Review
- Evolution of phenotypic plasticity owing to migration.Evolution letters · 2026Article
- Amoeba predation of Cryptococcus: A quantitative and population genomic evaluation of the accidental pathogen hypothesis.PLoS pathogens · 2023Article
- Gene by Environment Interactions reveal new regulatory aspects of signaling network plasticity.PLoS genetics · 2022Article
- Dissection of quantitative trait loci in the Lachancea waltii yeast species highlights major hotspots.G3 (Bethesda, Md.) · 2021Article
- Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence.PLoS genetics · 2021Article
- Flor Yeasts Rewire the Central Carbon Metabolism During Wine Alcoholic Fermentation.Frontiers in fungal biology · 2021Article
- Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes.Genes · 2020Article
- Dynamic genetic architecture of yeast response to environmental perturbation shed light on origin of cryptic genetic variation.PLoS genetics · 2020Article
- Quantitative Trait Nucleotides Impacting the Technological Performances of IndustrialFrontiers in genetics · 2019Article
- Dissection of the molecular bases of genotype x environment interactions: a study of phenotypic plasticity of Saccharomyces cerevisiae in grape juices.BMC genomics · 2018Article
- 2D association and integrative omics analysis in rice provides systems biology view in trait analysis.Communications biology · 2018Article
- Genetic Causes of Phenotypic Adaptation to the Second Fermentation of Sparkling Wines inG3 (Bethesda, Md.) · 2017Article
- The Interaction of Genotype and Environment Determines Variation in the Maize Kernel Ionome.G3 (Bethesda, Md.) · 2016Article
- Differential Regulation of Cryptic Genetic Variation Shapes the Genetic Interactome Underlying Complex Traits.Genome biology and evolution · 2016Article
- Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction.PLoS genetics · 2016Article
- Multi-locus Genotypes Underlying Temperature Sensitivity in a Mutationally Induced Trait.PLoS genetics · 2016Article
- Article
- Differential regulation of antagonistic pleiotropy in synthetic and natural populations suggests its role in adaptation.G3 (Bethesda, Md.) · 2015Article
- Spurious transcription factor binding: non-functional or genetically redundant?BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
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Authors and funding
8 authors.
Funding
Abstract
For a unicellular, nonmotile organism like Saccharomyces cerevisiae, carbon sources act as nutrients and as signaling molecules; consequently, these sources affect various fitness parameters, including growth. It is therefore advantageous for yeast strains to adapt their growth to carbon source variation. The ability of a given genotype to manifest different phenotypes in varying environments is known as phenotypic plasticity. To identify quantitative trait loci (QTL) that drive plasticity in growth, two growth parameters (growth rate and biomass) were measured for a set of meiotic recombinants of two genetically divergent yeast strains grown in different carbon sources. To identify QTL contributing to plasticity across pairs of environments, gene-environment interaction mapping was performed, which identified several QTL that have a differential effect across environments, some of which act antagonistically across pairs of environments. Multi-QTL analysis identified loci interacting with previously known growth affecting QTL as well as novel two-QTL interactions that affect growth. A QTL that had no significant independent effect was found to alter growth rate and biomass for several carbon sources through two-QTL interactions. Our study demonstrates that environment-specific epistatic interactions contribute to the growth plasticity in yeast. We propose that a targeted scan for epistatic interactions, such as the one described here, can help unravel mechanisms regulating phenotypic plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.