ArticleThe Laryngoscope2014
Collagen microstructure in the vocal ligament: initial results on the potential effects of smoking.
Article in The Laryngoscope, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 12 citations in OpenAlex.
- Which teachers are most at risk for voice disorders? Individual factors predicting vocal acoustic parameters monitored in situ during a workweek.International archives of occupational and environmental health · 2021Article
- Nonlinear viscoelastic characterization of human vocal fold tissues under large-amplitude oscillatory shear (LAOS).Journal of rheology · 2018Article
- High- and ultrahigh-field magnetic resonance imaging of naïve, injured and scarred vocal fold mucosae in rats.Disease models & mechanisms · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectives/hypothesisThis investigation quantitatively characterizes the collagenous microstructure of human vocal ligament specimens excised postmortem from nonsmokers and smokers. STUDY
designRetrospective cohort study.
methodsSecond harmonic generation (SHG) imaging was performed at three anatomical locations of vocal ligament specimens: anterior, mid-membranous, and posterior regions. Two microstructural parameters were extracted from the SHG images: (1) normalized fiber density, and (2) fiber dispersion coefficient, quantifying the degree of collagen fiber dispersion about a preferred direction.
resultsFor both the nonsmoker and smoker subjects, the fiber dispersion coefficient was heterogeneous. Differences in the collagenous structure of nonsmokers and smoker subjects were pronounced at the mid-membranous location. However, the directionality of the heterogeneity in the smoker subjects was opposite to that in the nonsmoker subjects. Specifically, the fiber dispersion coefficient in the nonsmoker subjects was lower in the mid-membranous region (indicating more fiber alignment) than at the anterior/posterior regions, but for the smoker subjects the fiber dispersion coefficient was higher at the mid-membranous region. The normalized fiber density was near constant in the nonsmoker subjects, but the smoker subjects had fewer fibers in the mid-membranous region than at the anterior/posterior regions.
conclusionSpatial microstructural variations may exist in the vocal fold ligament both in nonsmokers and smokers. Smoking appears to influence the degree and direction of microstructure heterogeneity in the vocal fold ligament.
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