ReviewThe Annals of pharmacotherapy2014
Medications and impaired driving.
Review in The Annals of pharmacotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Associations Between Falls and Driving Outcomes in Older Adults: Systematic Review and Meta-Analysis.Journal of the American Geriatrics Society · 2017Pooled it
- Alcohol consumption for simulated driving performance: A systematic review.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2017Pooled it
- An assessment of the centrally acting muscle relaxant tolperisone on driving ability and cognitive effects compared to placebo and cyclobenzaprine.Journal of clinical pharmacy and therapeutics · 2020Trial
- Impact of Anxiety and Anxiolytic Medication on Driving Outcomes in Older Adults: A LongROAD Study.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Driving after spine surgery: biomechanics, recovery pathways, and medico-legal insights.Journal of orthopaedic surgery and research · 2025Review
- Brain tumors and fitness to drive: A review and multi-disciplinary approach.Neuro-oncology practice · 2025Review
- New psychoactive substances in roadway crash victims in California.Frontiers in toxicology · 2025Article
- Dexamethasone is non-inferior to antihistamine plus dexamethasone premedication in preventing ramucirumab plus nab-paclitaxel infusion-related reactions in gastric cancer: a multicenter retrospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Implications of using administrative healthcare data to identify risk of motor vehicle crash-related injury: the importance of distinguishing crash from crash-related injury.Injury epidemiology · 2024Article
- Impact of cognitive impairment on driving behaviour and route choices of older drivers: a real-world driving study.Scientific reports · 2024Article
- Flight safety risk assessment of self-medication among fighter pilots: a cross-sectional study.International journal of clinical pharmacy · 2023Article
- Medication and Road Test Performance Among Cognitively Healthy Older Adults.JAMA network open · 2023Article
- Trends in the Use of Driving-Impairing Medicines According to the DRUID Category: A Population-Based Registry Study with Reference to Driving in a Region of Spain between 2015 and 2019.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Association of falls and fear of falling with objectively-measured driving habits among older drivers: LongROAD study.Journal of safety research · 2022Article
- Examining Patterns of Driving Avoidance Behaviors Among Older People Using Latent Class Analysis.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2022Article
- Development and Validation of Questionnaires on Professional Drivers' Knowledge and Attitudes About Various Medications' Influence on Driving Ability.Zdravstveno varstvo · 2022Article
- GABACurrent topics in behavioral neurosciences · 2022Review
- Potentially Inappropriate Medication Use and Hard Braking Events in Older Drivers.Geriatrics (Basel, Switzerland) · 2021Article
- Components of driving competency measurement in the elderly: A scoping review.Medical journal of the Islamic Republic of Iran · 2021Article
- Age-Related Diseases and Driving Safety.Geriatrics (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
objectiveTo describe the association of specific medication classes with driving outcomes and provide clinical recommendations. DATA SOURCES: The MEDLINE and EMBASE databases were searched for articles published from January 1973 to June 2013 on classes of medications associated with driving impairment. The search included outcome terms such as automobile driving, motor vehicle crash, driving simulator, and road tests. STUDY SELECTION AND DATA EXTRACTION: Only English-language articles that contained findings from observational or interventional designs with ≥ 10 participants were included in this review. Cross-sectional studies, case series, and case reports were excluded. DATA SYNTHESIS: Driving is an important task and activity for the majority of adults. Some commonly prescribed medications have been associated with driving impairment measured by road performance, driving simulation, and/or motor vehicle crashes. This review of 30 studies identified findings with barbiturates, benzodiazepines, hypnotics, antidepressants, opioid and nonsteroidal analgesics, anticonvulsants, antipsychotics, antiparkinsonian agents, skeletal muscle relaxants, antihistamines, anticholinergic medications, and hypoglycemic agents. Additional studies of medication impact on sedation, sleep latency, and psychomotor function, as well as the role of alcohol, are also discussed.
conclusionsPsychotropic agents and those with central nervous system side effects were associated with measures of impaired driving performance. It is difficult to determine if such associations are actually a result of medication use or the medical diagnosis itself. Regardless, clinicians should be aware of the increased risk of impaired driving with specific classes of medications, educate their patients, and/or consider safer alternatives.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.