ReviewNature neuroscience2014
Normal and abnormal coding of somatosensory stimuli causing pain.
Review in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Morpho-Histo-Cytological Evaluation of Oral Tissues in Burning Mouth Syndrome: A Systematic Review.Journal of oral rehabilitation · 2025Pooled it
- The efficiency of tactile discrimination training and oculomotor exercises in people with chronic neck pain: a randomized controlled trial.BMC musculoskeletal disorders · 2025Trial
- Article
- Dual-frequency spinal cord stimulation increases responder rates for treatment of neuropathic pain.Pain · 2026Article
- An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Vagal neuropathies: An underrecognized potential driver of physical, mental, and immune symptoms.Brain, behavior, & immunity - health · 2026Review
- Spinal Processing of Spatiotemporally Diverse Tactile Stimuli: Computational Insights into Allodynia and Spinal Cord Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Prediction error coding as the computational basis for nocifensive and nocifensive-like behaviors.Frontiers in neuroscience · 2026Article
- The dorsal column nuclei encode and transmit the network signatures of mechanical allodynia.Cell reports · 2025Article
- The Effect of Pexidartinib on Neuropathic Pain via Influences on Microglia and Neuroinflammation in Mice.Anesthesia and analgesia · 2025Article
- How microglia contribute to the induction and maintenance of neuropathic pain.Nature reviews. Neuroscience · 2025Review
- Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord.Nature neuroscience · 2025Article
- Differential modification of ascending spinal outputs in acute and chronic pain states.Neuron · 2025Article
- Mrgprb4-lineage neurons indispensable in pressure induced pleasant sensation are polymodal.iScience · 2025Article
- Survey of temporal coding of sensory information.Frontiers in computational neuroscience · 2025Article
- Review
- Encoding of Vibrotactile Stimuli by Mechanoreceptors in Rodent Glabrous Skin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain.The Journal of general physiology · 2024Article
- A multichannel electrophysiological approach to noninvasively and precisely record human spinal cord activity.PLoS biology · 2024Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Noxious stimuli usually cause pain and pain usually arises from noxious stimuli, but exceptions to these apparent truisms are the basis for clinically important problems and provide valuable insight into the neural code for pain. In this Review, we discuss how painful sensations arise. We argue that, although primary somatosensory afferents are tuned to specific stimulus features, natural stimuli often activate more than one type of afferent. Manipulating coactivation patterns can alter perception in ways that argue against each type of afferent acting independently (as expected for strictly labeled lines), suggesting instead that signals conveyed by different types of afferents interact. Deciphering the central circuits that mediate those interactions is critical for explaining the generation and modulation of neural signals that ultimately elicit pain. The advent of genetic and optical dissection techniques promise to dramatically accelerate progress toward this goal, which will facilitate the rational design of future pain therapeutics.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.