ArticleReproduction (Cambridge, England)2014
Placental development during early pregnancy in sheep: effects of embryo origin on vascularization.
Article in Reproduction (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Analyses of child cardiometabolic phenotype following assisted reproductive technologies using a pragmatic trial emulation approach.Nature communications · 2021Trial
- Development of a non-invasive diagnostic model for severe Retinopathy of Prematurity integrating clinical and platelet data.Scientific reports · 2025Article
- Epithelial-Mesenchymal Transitions Leading to Conceptus Adhesion in Ruminants: Early Pregnancy Events in Cattle.International journal of molecular sciences · 2025Review
- Single nucleotide polymorphism-based analysis of linkage disequilibrium and runs of homozygosity patterns of indigenous sheep in the southern Taklamakan desert.BMC genomics · 2025Article
- Association of assisted reproductive technology with adverse maternal outcome: A cohort study.Pakistan journal of medical sciences · 2025Article
- Role of the placenta in developmental programming: Observations from models using large animals.Animal reproduction science · 2023Review
- In vitro- and in vivo-produced male dairy calves show molecular differences in the hepatic and muscular energy regulation†.Biology of reproduction · 2022Article
- Nutritional Regulation of Embryonic Survival, Growth, and Development.Advances in experimental medicine and biology · 2022Review
- Fitness of calves born fromFrontiers in veterinary science · 2022Article
- Programming of Embryonic Development.International journal of molecular sciences · 2021Review
- Epigenomic and transcriptomic analyses reveal early activation of the HPG axis in in vitro-produced male dairy calves.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Maternal periconceptual nutrition, early pregnancy, and developmental outcomes in beef cattle.Journal of animal science · 2020Review
- Bone-marrow-derived endothelial progenitor cells contribute to vasculogenesis of pregnant mouse uterus†.Biology of reproduction · 2019Article
- Placental development during early pregnancy in sheep: nuclear estrogen and progesterone receptor mRNA expression in the utero-placental compartments.Domestic animal endocrinology · 2019Article
- Neurodevelopment at Age 10 Years of Children Born <28 Weeks With Fetal Growth Restriction.Pediatrics · 2017Observational
- Placental pathology and hypospadias.Pediatric research · 2017Article
- Synergies between assisted reproduction technologies and functional genomics.Genetics, selection, evolution : GSE · 2016Review
- Placental development during early pregnancy: Effects of embryo origin on expression of chemokine ligand twelve (CXCL12).Placenta · 2016Article
- Phosphoinositide 3-Kinase (PI3K) Subunit p110δ Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse.Scientific reports · 2016Article
- The placenta: phenotypic and epigenetic modifications induced by Assisted Reproductive Technologies throughout pregnancy.Clinical epigenetics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Utero-placental growth and vascular development are critical for pregnancy establishment that may be altered by various factors including assisted reproductive technologies (ART), nutrition, or others, leading to compromised pregnancy. We hypothesized that placental vascularization and expression of angiogenic factors are altered early in pregnancies after transfer of embryos created using selected ART methods. Pregnancies were achieved through natural mating (NAT), or transfer of embryos from NAT (NAT-ET), or IVF or in vitro activation (IVA). Placental tissues were collected on day 22 of pregnancy. In maternal caruncles (CAR), vascular cell proliferation was less (P<0.05) for IVA than other groups. Compared with NAT, density of blood vessels was less (P<0.05) for IVF and IVA in fetal membranes (FM) and for NAT-ET, IVF, and IVA in CAR. In FM, mRNA expression was decreased (P<0.01-0.08) in NAT-ET, IVF, and IVA compared with NAT for vascular endothelial growth factor (VEGF) and its receptor FLT1, placental growth factor (PGF), neuropilin 1 (NP1) and NP2, angiopoietin 1 (ANGPT1) and ANGPT2, endothelial nitric oxide synthase 3 (NOS3), hypoxia-inducible factor 1A (HIF1A), fibroblast growth factor 2 (FGF2), and its receptor FGFR2. In CAR, mRNA expression was decreased (P<0.01-0.05) in NAT-ET, IVF, and IVA compared with NAT for VEGF, FLT1, PGF, ANGPT1, and TEK. Decreased mRNA expression for 12 of 14 angiogenic factors across FM and CAR in NAT-ET, IVF, and IVA pregnancies was associated with reduced placental vascular development, which would lead to poor placental function and compromised fetal and placental growth and development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.