ReviewThe British journal of radiology2014
Radiation-mediated formation of complex damage to DNA: a chemical aspect overview.
Review in The British journal of radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review.Particle and fibre toxicology · 2023Pooled it
- Reactive oxygen species in health and disease.Molecular biomedicine · 2026Review
- Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types.Nature genetics · 2026Article
- Reactive Oxygen Species: Molecular Mechanisms, Cellular Targets, and Implications for Genomic Stability.BioMed research international · 2026Review
- Assessing the radiation-induced bystander effect in radionuclide therapy using targeted radiopharmaceuticals.EJNMMI radiopharmacy and chemistry · 2025Article
- Review
- Assessment of Radiation Hazard Indices Due to Natural Radionuclides in Soil Samples from Imo State University, Owerri, Nigeria.Environmental health insights · 2024Article
- Radiation-associated secondary malignancies: a novel opportunity for applying immunotherapies.Cancer immunology, immunotherapy : CII · 2023Review
- Hydroxyl Radical vs. One-Electron Oxidation Reactivities in an Alternating GC Double-Stranded Oligonucleotide: A New Type Electron Hole Stabilization.Biomolecules · 2023Article
- Clustered DNA Damage Patterns after Proton Therapy Beam Irradiation Using Plasmid DNA.International journal of molecular sciences · 2022Article
- The Two Faces of the Guanyl Radical: Molecular Context and Behavior.Molecules (Basel, Switzerland) · 2021Review
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans.Journal of pineal research · 2021Article
- Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast.Archives of toxicology · 2020Review
- Genomic and transcriptomic comparison of post-radiation versus sporadic sarcomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- Biopsy of palliative lesions following radiotherapy.BJR open · 2019Article
- Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis.Antioxidants & redox signaling · 2018Review
- Profiles of Radioresistance Mechanisms in Prostate Cancer.Critical reviews in oncogenesis · 2018Review
- Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer.Cancers · 2017Review
- Mutational signatures of ionizing radiation in second malignancies.Nature communications · 2016Article
- Stress-induced DNA damage biomarkers: applications and limitations.Frontiers in chemistry · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last three decades, a considerable amount of work has been undertaken to determine the nature, the mechanism of formation and the biological consequences of radiation-induced DNA lesions. Most of the information was obtained via the development of chemical approaches, including theoretical, analytical and organic synthesis methods. Since it is not possible to present all the results obtained in this review article, we will focus on recent data dealing with the formation of complex DNA lesions produced by a single oxidation event, as these lesions may play a significant role in cellular responses to ionizing radiation and also to other sources of oxidative stress. Through the description of specific results, the contribution of different chemical disciplines in the assessment of the structure, the identification of the mechanism of formation and the biological impacts in terms of repair and mutagenicity of these complex radiation-induced DNA lesions will be highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.