ArticleLongevity & healthspan2012
From cellular senescence to age-associated diseases: the miRNA connection.
Article in Longevity & healthspan, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Antibiotic-Induced Genotoxicity: Molecular Mechanisms, Cytogenetic Damage, and Implications for Human Health.International journal of molecular sciences · 2026Review
- Mango, the king of fruits, with fascinating pharmacological activities and medicinal uses.Open veterinary journal · 2025Review
- The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches.Biomolecules · 2024Review
- Genomic Instability and Epigenetic Changes during Aging.International journal of molecular sciences · 2023Review
- Mango (Antioxidants (Basel, Switzerland) · 2021Review
- Association study of leukocyte telomere length and genetic polymorphism within hTERT promoter with type 2 diabetes in Bangladeshi population.Molecular biology reports · 2021Article
- Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms.Scientific reports · 2019Article
- Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages.Redox biology · 2018Article
- Article
- A step-by-step microRNA guide to cancer development and metastasis.Cellular oncology (Dordrecht, Netherlands) · 2017Review
- The Immortal Senescence.Methods in molecular biology (Clifton, N.J.) · 2017Review
- Unexploited Antineoplastic Effects of Commercially Available Anti-Diabetic Drugs.Pharmaceuticals (Basel, Switzerland) · 2016Review
- MicroRNAs; easy and potent targets in optimizing therapeutic methods in reparative angiogenesis.Journal of cellular and molecular medicine · 2015Review
- Article
- miRNA control of tissue repair and regeneration.The American journal of pathology · 2015Review
- Cellular senescence: a hitchhiker's guide.Human cell · 2015Review
- Absence of mutation in miR-34a gene in a Chinese longevity population.Dong wu xue yan jiu = Zoological research · 2015Article
- Integromics network meta-analysis on cardiac aging offers robust multi-layer modular signatures and reveals micronome synergism.BMC genomics · 2015Article
- Structure of precursor microRNA's terminal loop regulates human Dicer's dicing activity by switching DExH/D domain.Protein & cell · 2015Article
- The role of microRNAs in cellular senescence and age-related conditions of cartilage and bone.Acta orthopaedica · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cellular senescence has evolved from an in-vitro model system to study aging in vitro to a multifaceted phenomenon of in-vivo importance as senescent cells in vivo have been identified and their removal delays the onset of age-associated diseases in a mouse model system. From the large emerging class of non-coding RNAs, miRNAs have only recently been functionally implied in the regulatory networks that are modified during the aging process. Here we summarize examples of similarities between the differential expression of miRNAs during senescence and age-associated diseases and suggest that these similarities might emphasize the importance of senescence for the pathogenesis of age-associated diseases. Understanding such a connection on the level of miRNAs might offer valuable opportunities for designing novel diagnostic and therapeutic strategies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.