ArticleClinical and translational science2014
A national strategy to develop pragmatic clinical trials infrastructure.
Article in Clinical and translational science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Implementation Strategies for Strengthening Community and Stakeholder Engagement in Clinical and Translational Pilot Studies.Journal of participatory research methods · 2026Article
- Intervention delivery complexity and adaptations for implementation of non-pharmacologic pain interventions.Contemporary clinical trials communications · 2025Article
- Fidelity to the acupuncture intervention protocol in the ACUpuncture In The EmergencY department for pain management (ACUITY) trial: Expanding the gold standard of STRICTA and CONSORT guidelines.Integrative medicine research · 2024Article
- Article
- Design, implementation, and inferential issues associated with clinical trials that rely on data in electronic medical records: a narrative review.BMC medical research methodology · 2023Review
- Sample size requirements for detecting treatment effect heterogeneity in cluster randomized trials.Statistics in medicine · 2020Article
- Can Electronic Health Records Validly Estimate the Effects of Health System Interventions Aimed at Controlling Body Weight?Obesity (Silver Spring, Md.) · 2020Article
- Defining key design elements of registry-based randomised controlled trials: a scoping review.Trials · 2020Article
- Value-Based Care for Musculoskeletal Pain: Are Physical Therapists Ready to Deliver?Physical therapy · 2020Article
- Informed consent and community engagement in open field research: lessons for gene drive science.BMC medical ethics · 2019Article
- Academic Consortium for Integrative Medicine & Health Commentary to Health and Human Services (HHS) on Inter-agency Task Force Pain Management Best Practices Draft Report.Global advances in health and medicine · 2019Article
- Academic Consortium for Integrative Medicine & Health Commentary to CMS; RE: National Coverage Analysis (NCA) Tracking Sheet for Acupuncture for Chronic Low Back Pain (CAG-00452N).Global advances in health and medicine · 2019Article
- OneFlorida Clinical Research Consortium: Linking a Clinical and Translational Science Institute With a Community-Based Distributive Medical Education Model.Academic medicine : journal of the Association of American Medical Colleges · 2018Article
- Better Together: The Making and Maturation of the Palliative Care Research Cooperative Group.Journal of palliative medicine · 2017Article
- Validation of clinic weights from electronic health records against standardized weight measurements in weight loss trials.Obesity (Silver Spring, Md.) · 2017Article
- Measuring the Value of Pharmaceuticals in the US Health System.PharmacoEconomics · 2017Article
- Practice-based Research Networks (PBRNs) in the Era of Integrated Delivery Systems.Journal of the American Board of Family Medicine : JABFMReview
- Cochrane reviews on acupuncture therapy for pain: A snapshot of the current evidence.Explore (New York, N.Y.)Article
- Guidance for researchers developing and conducting clinical trials in practice-based research networks (PBRNs).Journal of the American Board of Family Medicine : JABFMArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
An important challenge in comparative effectiveness research is the lack of infrastructure to support pragmatic clinical trials, which compare interventions in usual practice settings and subjects. These trials present challenges that differ from those of classical efficacy trials, which are conducted under ideal circumstances, in patients selected for their suitability, and with highly controlled protocols. In 2012, we launched a 1-year learning network to identify high-priority pragmatic clinical trials and to deploy research infrastructure through the NIH Clinical and Translational Science Awards Consortium that could be used to launch and sustain them. The network and infrastructure were initiated as a learning ground and shared resource for investigators and communities interested in developing pragmatic clinical trials. We followed a three-stage process of developing the network, prioritizing proposed trials, and implementing learning exercises that culminated in a 1-day network meeting at the end of the year. The year-long project resulted in five recommendations related to developing the network, enhancing community engagement, addressing regulatory challenges, advancing information technology, and developing research methods. The recommendations can be implemented within 24 months and are designed to lead toward a sustained national infrastructure for pragmatic trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.