ArticleJournal of medicinal chemistry2014
A simple litmus test for aldehyde oxidase metabolism of heteroarenes.
Article in Journal of medicinal chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 53 citations in OpenAlex.
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- Predicting liver cytosol stability of small molecules.Journal of cheminformatics · 2020Article
- Scaffold-hopping as a strategy to address metabolic liabilities of aromatic compounds.RSC medicinal chemistry · 2020Review
- Late-StageAngewandte Chemie (International ed. in English) · 2019Article
- SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization.Journal of the American Chemical Society · 2018Article
- Radicals: Reactive Intermediates with Translational Potential.Journal of the American Chemical Society · 2016Review
- 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.ACS medicinal chemistry letters · 2016Article
- Academia-industry symbiosis in organic chemistry.Accounts of chemical research · 2015Article
- Improving physical properties via C-H oxidation: chemical and enzymatic approaches.Angewandte Chemie (International ed. in English) · 2014Article
- Simple sulfinate synthesis enables C-H trifluoromethylcyclopropanation.Angewandte Chemie (International ed. in English) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The bioavailability of aromatic azaheterocyclic drugs can be affected by the activity of aldehyde oxidase (AO). Susceptibility to AO metabolism is difficult to predict computationally and can be complicated in vivo by differences between species. Here we report the use of bis(((difluoromethyl)sulfinyl)oxy)zinc (DFMS) as a source of CF2H radical for a rapid and inexpensive chemical "litmus test" for the early identification of heteroaromatic drug candidates that have a high probability of metabolism by AO.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.