ReviewThe journal of obstetrics and gynaecology research2014
Role of pelvic and para-aortic lymphadenectomy in endometrial cancer: current evidence.
Review in The journal of obstetrics and gynaecology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- Comparison of Robotic-Assisted vs. Conventional Laparoscopy for Para-aortic Lymphadenectomy in Gynecological Malignancies: A Systematic Review and Meta-Analysis.Frontiers in surgery · 2022Pooled it
- Transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial infiltration in patients with endometrial cancer: a systematic review and meta-analysis.Journal of gynecologic oncology · 2017Pooled it
- Lymphadenectomy for the management of endometrial cancer.The Cochrane database of systematic reviews · 2017Pooled it
- Lymphadenectomy for the management of endometrial cancer.The Cochrane database of systematic reviews · 2015Pooled it
- Minimizing Lymphatic Morbidity: Incidence of Lower Extremity Lymphedema After vNOTES-Assisted Sentinel Node Mapping in Endometrial Cancer.Current oncology (Toronto, Ont.) · 2026Article
- Annual nationwide cost estimation and short-term outcomes after para-aortic lymph node dissection for gynecologic malignancies according to surgical approach (open, laparoscopic, and robotic).Journal of robotic surgery · 2025Article
- Serum Levels of CA125 and HE4 as a Tool for Predicting Regional Lymph Node Metastatic Involvement in Endometrial Carcinoma.Cancers · 2025Article
- Review
- Oncologic Outcome of Robotic-Assisted and Laparoscopic Sentinel Node Biopsy in Endometrial Cancer.Cancers · 2023Article
- Demographic Factors Predict Risk of Lymph Node Involvement in Patients with Endometrial Adenocarcinoma.Biology · 2023Article
- Sentinel lymph node mapping in endometrial cancer to reduce surgical morbidity: always, sometimes, or never.Przeglad menopauzalny = Menopause review · 2022Review
- Article
- Endometrial carcinoma: use of tracer kinetic modeling of dynamic contrast-enhanced MRI for preoperative risk assessment.Cancer imaging : the official publication of the International Cancer Imaging Society · 2022Article
- Paraaortic Lymphadenectomy in Gynecologic Oncology-Significance of Vessels Variations.Journal of clinical medicine · 2022Review
- Is routine frozen section analysis necessary in patients with non-endometrioid cancer or grade 3 endometrioid cancer?International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022Article
- Automatic segmentation of uterine endometrial cancer on multi-sequence MRI using a convolutional neural network.Scientific reports · 2021Article
- Survival outcomes and prognostic factors of endometrial stromal sarcoma and undifferentiated uterine sarcoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
- Challenges Posed by Embryonic and Anatomical Factors in Systematic Lymphadenectomy for Endometrial Cancer.Journal of clinical medicine · 2020Review
- Sentinel lymph node intraoperative analysis in endometrial cancer.Journal of cancer research and clinical oncology · 2020Article
- Diagnostic accuracy and economic impact of three work-up strategies identifying risk groups in endometrial cancer, fully incorporating sentinel lymph node algorithm.Facts, views & vision in ObGyn · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The aim of the present review is to summarize the current evidence on the role of pelvic and para-aortic lymphadenectomy in endometrial cancer. In 1988, the International Federation of Obstetrics and Gynecology recommended surgical staging for endometrial cancer patients. However, 25 years later, the role of lymph node dissection remains controversial. Although the findings of two large independent randomized trials suggested that pelvic lymphadenectomy provides only adjunctive morbidity with no clear influence on survival outcomes, the studies have many pitfalls that limit interpretation of the results. Theoretically, lymphadenectomy may help identify patients with metastatic dissemination, who may benefit from adjuvant therapy, thus reducing radiation-related morbidity. Also, lymphadenectomy may eradicate metastatic disease. Because lymphatic spread is relatively uncommon, our main effort should be directed at identifying patients who may potentially benefit from lymph node dissection, thus reducing the rate of unnecessary treatment and associated morbidity. This review will discuss the role of lymphadenectomy in endometrial cancer, focusing on patient selection, extension of the surgical procedure, postoperative outcomes, quality of life and costs. The need for new surgical studies and efficacious systemic drugs is recommended.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.