ReviewParasite immunology2014
Pregnancy and helminth infections.
Review in Parasite immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Malaria and Helminthic Co-Infection during Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Systematic review to evaluate a potential association between helminth infection and physical stunting in children.Parasites & vectors · 2022Pooled it
- Intestinal parasitic infections and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2021Pooled it
- Plasmodium and intestinal parasite perturbations of the infected host's inflammatory responses: a systematic review.Parasites & vectors · 2018Pooled it
- Factors associated with soil-transmitted helminths infection in Benin: Findings from the DeWorm3 study.PLoS neglected tropical diseases · 2021Trial
- Long-term outcomes of ivermectin-albendazole versus albendazole alone against soil-transmitted helminths: Results from randomized controlled trials in Lao PDR and Pemba Island, Tanzania.PLoS neglected tropical diseases · 2021Trial
- Performance of the Kato-Katz method and real time polymerase chain reaction for the diagnosis of soil-transmitted helminthiasis in the framework of a randomised controlled trial: treatment efficacy and day-to-day variation.Parasites & vectors · 2020Trial
- Placental gene expression and antibody levels of mother-neonate pairs reveal an enhanced risk for inflammation in a helminth endemic country.Scientific reports · 2019Trial
- Cord blood Streptococcus pneumoniae-specific cellular immune responses predict early pneumococcal carriage in high-risk infants in Papua New Guinea.Clinical and experimental immunology · 2017Trial
- The impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: Secondary analysis of a randomised controlled trial.PLoS neglected tropical diseases · 2017Trial
- The female reproductive tract-gut axis in gastrointestinal parasitic infection.PLoS pathogens · 2025Review
- Malaria and soil transmitted helminth infection and associated factors among pregnant women attending public health facilities in Dilla town, South Ethiopia: cross sectional study design.BMC infectious diseases · 2025Article
- Article
- Lifestyle score is associated with cellular immune profiles in healthy Tanzanian adults.Brain, behavior, & immunity - health · 2024Article
- Impact of helminth infections during pregnancy on maternal and newborn Vitamin D and on birth outcomes.Scientific reports · 2024Article
- Immunological factors linked to geographical variation in vaccine responses.Nature reviews. Immunology · 2024Review
- Iron supplementation and deworming during pregnancy reduces the risk of anemia and stunting in infants less than 2 years of age: a study from Sub-Saharan Africa.BMC pregnancy and childbirth · 2023Article
- Prevalence and contributing factors of anaemia among children aged 6-24 months and 25-59 months in Mali.Journal of nutritional science · 2023Article
- Micronutrients deficiencies and its correlation with the soil-transmitted helminthic infections among children and non-pregnant women in Nepal: findings from Nepal national micronutrient status survey.Scientific reports · 2022Article
- A large-scale epidemiological investigation on trematode infections in small ruminants in Bangladesh.Veterinary medicine and science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
It has been proposed that helminth infection may be particularly detrimental during pregnancy, through adverse effects on maternal anaemia and on birth outcomes, and that anthelminthic treatment during pregnancy will therefore be particularly beneficial. However, the few treatment trials that have been conducted have given, but little support to this notion and further trials in settings of nutritional stress are needed. It has also been proposed that prenatal exposure to helminth infection has an important effect on the development of the foetal immune response. There is evidence that this may impact, long-term, upon responses to helminth and nonhelminth antigens, and to allergens. Exposure to helminths in utero may also have nonspecific effects that may modify the offspring's susceptibility to diseases mediated by inflammation, including metabolic disorders. The mechanisms of such effects are not known, but they deserve to be explored as current epidemiological findings suggest the possibility of primary prevention for inflammatory conditions such as allergy, through intervention during pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.