ArticleThe Journal of clinical endocrinology and metabolism2014
Placental CYP27B1 and CYP24A1 expression in human placental tissue and their association with maternal and neonatal calcitropic hormones.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Vitamin D-Related Risk Factors for Maternal Morbidity during Pregnancy: A Systematic Review.Nutrients · 2022Pooled it
- Effects of High-Dose Vitamin D Supplementation on Placental Vitamin D Metabolism and Neonatal Vitamin D Status.Nutrients · 2024Trial
- Hypercalcemia due toJBMR plus · 2025Article
- Molecular pathways in placental-fetal development and disruption.Molecular and cellular endocrinology · 2024Review
- Placental Erythroferrone and Erythropoietin mRNA Expression is not Associated with Maternal or Neonatal Iron Status in Adolescents Carrying Singletons and Adult Women Carrying Multiples.The Journal of nutrition · 2023Article
- Decreased Vitamin D Levels and Altered Placental Vitamin D Gene Expression at High Altitude: Role of Genetic Ancestry.International journal of molecular sciences · 2023Article
- Associations between maternal vitamin D status and porcine litter characteristics throughout gestation.Journal of animal science and biotechnology · 2022Article
- Megalin and Vitamin D Metabolism-Implications in Non-Renal Tissues and Kidney Disease.Nutrients · 2022Review
- Uptake of Phosphate, Calcium, and Vitamin D by the Pregnant Uterus of Sheep in Late Gestation: Regulation by Chorionic Somatomammotropin Hormone.International journal of molecular sciences · 2022Article
- Effects of exogenous progesterone on the expression of mineral regulatory molecules by ovine endometrium and placentomes†.Biology of reproduction · 2022Article
- Effects of progesterone and interferon tau on ovine endometrial phosphate, calcium, and vitamin D signaling†.Biology of reproduction · 2022Article
- Vitamin D Supplementation Improves Mitochondrial Function and Reduces Inflammation in Placentae of Obese Women.Frontiers in endocrinology · 2022Article
- Review
- Multiple Sclerosis: Lipids, Lymphocytes, and Vitamin D.Immunometabolism · 2020Article
- Effects of 1,25 and 24,25 Vitamin D on Corneal Epithelial Proliferation, Migration and Vitamin D Metabolizing and Catabolizing Enzymes.Scientific reports · 2017Article
- Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts.Endocrinology · 2017Article
- Article
- Maternal iron status during pregnancy compared with neonatal iron status better predicts placental iron transporter expression in humans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Decreased serum vitamin D levels in early spontaneous pregnancy loss.European journal of clinical nutrition · 2016Article
- Vitamin D status is inversely associated with anemia and serum erythropoietin during pregnancy.The American journal of clinical nutrition · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
contextPlacental CYP27B1 may contribute to circulating maternal calcitriol concentrations across gestation, but determinants of CYP27B1 and CYP24A1 expression in term human placental tissue are not well established.
objectiveWe hypothesized that higher CYP27B1 protein expression would be associated with increased maternal calcitriol during gestation and that CYP27B1 expression would be impacted by substrate availability.
designThis was a prospective, longitudinal study.
settingThe study was completed in an urban, prenatal clinic located in Rochester, New York. PATIENTS: The study was undertaken in a cohort of 70 pregnant adolescents (≤18 y of age) and their term neonates.
interventionThere was no intervention. MAIN OUTCOMES: Protein and mRNA expressions of CYP27B1, CYP24A1, and vitamin D receptor were measured in term placental tissue and related to 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D, PTH, serum total calcium, IL-6, leptin, and osteoprotegerin measured in maternal serum at midgestation and delivery and in umbilical cord serum at birth.
resultsPlacental CYP27B1 protein expression was significantly positively associated with maternal 25(OH)D at both midgestation (n = 68, P = .009) and delivery (n=67, P = .006). Maternal serum 1,25-dihydroxyvitamin D concentrations at midgestation were positively correlated with term placental CYP27B1 mRNA expression (n = 49, P = .002). Significant positive associations were evident between placental CYP27B1 and CYP24A1 protein expression (P = .001, n = 70). Maternal PTH concentrations at midgestation or delivery did not significantly impact placental protein or transcript level of either enzyme. Variability in placental CYP27B1 protein expression was best captured by a model that included maternal midgestation 25(OH)D concentration, placental vitamin D receptor protein expression, and maternal midgestation IL-6 concentrations (P = .002, n = 60, R(2) = 0.22).
conclusionsHigher maternal 25(OH)D during pregnancy was associated with significantly higher placental protein expression of CYP27B1 at term supportive of a link between substrate availability and placental production of calcitriol.
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Registered trials
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