ArticlePreventive nutrition and food science2012
Hypoglycemic Effect of Padina arborescens Extract in Streptozotocin-induced Diabetic Mice.
Article in Preventive nutrition and food science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Ethanolic Extract ofInternational journal of molecular sciences · 2026Article
- Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes.Marine drugs · 2024Review
- Investigation of Physical Characteristics and In Vitro Anti-Inflammatory Effects of Fucoidan fromMarine drugs · 2024Article
- Chemical Composition and Evaluation of theEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Postprandial Antihyperglycemic And Antioxidant Activities ofPharmacognosy magazine · 2016Article
- Potential Bioactive Compounds from Seaweed for Diabetes Management.Marine drugs · 2015Review
- Padina arborescens extract protects high glucose-induced apoptosis in pancreatic β cells by reducing oxidative stress.Nutrition research and practice · 2014Article
- The role ofAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the hypoglycemic effect of the Padina arborescens extract in STZ-induced diabetic mice. Freeze-dried Padina arborescens were extracted with 80% methanol and concentrated for use in this study. The hypoglycemic effect was determined by inhibitory activities against α-glucosidase and α-amylase as well as the alleviation of postprandial blood glucose level. Padina arborescens extracts showed higher inhibitory activities than acarbose, a positive control against α-glucosidase and α-amylase. The IC50 values of Padina arborescens extracts against α-glucosidase and α-amylase were 0.26 and 0.23 mg/mL, respectively, which evidenced as more effective than observed with acarbose. The increase of postprandial blood glucose levels were significantly suppressed in the Padina arborescens extract administered group than the control group in the streptozotocin induced diabetic mice. Furthermore, the area under the curve (AUC) was significantly lowered via Padina arborescens extract administration in diabetic mice (p < 0.05). These results indicated that the Padina arborescens extract might be used as an inhibitor of α-glucosidase and α-amylase and delay absorption of dietary carbohydrates.
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Registered trials
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