ArticlePreventive nutrition and food science2012
Anti-hyperlipidemic Effect of Polyphenol Extract (Seapolynol(™)) and Dieckol Isolated from Ecklonia cava in in vivo and in vitro Models.
Article in Preventive nutrition and food science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Study protocol for a double-blind randomised controlled trial investigating the impact of 12 weeks supplementation with aBMJ open · 2018Trial
- Dieckol suppresses lipid accumulation and promotes thermogenic markers in 3T3-L1 adipocytes via ERK/p38 MAPK signaling.Journal of physiology and biochemistry · 2026Article
- Antidiabetic Effects ofMarine drugs · 2026Article
- Brown AlgaeMarine drugs · 2024Article
- Exploring the Hypocholesterolemic Potential of aMarine drugs · 2024Article
- The Hypocholesterolemic Potential of the Edible AlgaeFoods (Basel, Switzerland) · 2023Article
- Roles of Marine Macroalgae or Seaweeds and Their Bioactive Compounds in Combating Overweight, Obesity and Diabetes: A Comprehensive Review.Marine drugs · 2023Review
- The Ameliorative Effect and Mechanisms ofNutrients · 2022Article
- A Bioactive Substance Derived from Brown Seaweeds: Phlorotannins.Marine drugs · 2022Review
- Anti-Obesity Effects ofAntioxidants (Basel, Switzerland) · 2022Article
- Article
- Brown Algae Potential as a Functional Food against Hypercholesterolemia: Review.Foods (Basel, Switzerland) · 2021Review
- Bioactive Properties of Marine Phenolics.Marine drugs · 2020Review
- Seaweed's Bioactive Candidate Compounds to Food Industry and Global Food Security.Life (Basel, Switzerland) · 2020Review
- Seaweed Phenolics: From Extraction to Applications.Marine drugs · 2020Review
- Effect of Food Preparations on In Vitro Bioactivities and Chemical Components ofFoods (Basel, Switzerland) · 2020Article
- Safety ofEFSA journal. European Food Safety Authority · 2017Article
- An extract from the Atlantic brown algaeOncotarget · 2017Article
- Seapolynol Extracted from Ecklonia cava Inhibits Adipocyte Differentiation in Vitro and Decreases Fat Accumulation in Vivo.Molecules (Basel, Switzerland) · 2015Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inhibitory effect of polyphenol extracts (Seapolynol(™), SPN) of the marine brown algae Ecklonia cava and dieckol, a major component of SPN, on hyperlipidemia was investigated in ICR mice fed a high-fat diet (HFD) for five weeks. For analysis of the anti-hyperlipidemic effects of SPN and dieckol, these two agents were given orally on a daily basis to HFD-fed mice for four weeks, starting one week after the beginning of HFD feeding. Groups administered with SPN as well as dieckol showed lower body weight gains than the HFD only group. Administration of SPN and dieckol also resulted in a significant reduction of the level of total cholesterol (TCHO), triglyceride (TG), and low-density lipoprotein (LDL) cholesterol in the serum of HFD-fed mice. In Oil Red O staining using 3T3-L1 preadipocytes, it was shown that both SPN and dieckol markedly inhibited lipid accumulation of 3T3-L1 cells. Furthermore, SPN and dieckol (50 μg/mL) significantly inhibited 3-hydroxyl-methyl glutaryl coenzyme A (HMGCoA) reductase activity in vitro. Taken together, these results suggest that polyphenols of Ecklonia cava (SPN) and dieckol reduce body weight gain and fat accumulation in HFD-induced obese mice, and that their hypolipidemic effect is related to the inhibition of adipogenesis of adipocytes and HMGCoA reductase activity.
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