Evidence map›Paper›PMID 24470840›Full record

ArticleACS medicinal chemistry letters2013

Desmethyl Macrolides: Synthesis and Evaluation of 4,8,10-Tridesmethyl Cethromycin.

Bharat Wagh, Tapas Paul, Charles Debrosse, Dorota Klepacki, Meagan C Small, Alexander D Mackerell, Rodrigo B Andrade

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Computer-Aided Drug Design Methods.Methods in molecular biology (Clifton, N.J.) · 2017
    Article
  5. Article
  6. The evolving role of chemical synthesis in antibacterial drug discovery.Angewandte Chemie (International ed. in English) · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Bharat WaghDepartment of Chemistry, Temple University, Philadelphia, PA 19122.
Tapas PaulDepartment of Chemistry, Temple University, Philadelphia, PA 19122.
Charles DebrosseDepartment of Chemistry, Temple University, Philadelphia, PA 19122.
Dorota KlepackiCenter for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607.
Meagan C SmallDepartment of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201.
Alexander D MackerellDepartment of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201.
Rodrigo B AndradeDepartment of Chemistry, Temple University, Philadelphia, PA 19122.
Temple University · USUniversity of Maryland, Baltimore · USUniversity of Illinois Chicago · US

Funding

Carbohydrate force fields for structure, dynamics and molecular recognitionR01GM070855 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI MACKERELL, ALEXANDER D · 2005 to 2018
$3.5M
Discovery of Novel Macrolide AntibioticsR01AI080968 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI ANDRADE, RODRIGO B · 2009 to 2012
$1.3M
NIAID NIH HHS R01 AI080968NIGMS NIH HHS R01 GM070855
6 · The paper itself

Abstract

Antibiotic-resistant bacteria are emerging at an alarming rate in both hospital and community settings. Motivated by this issue, we have prepared desmethyl (i.e., replacing methyl groups with hydrogens) analogues of third-generation macrolide drugs telithromycin (TEL,

Indexed as

antibiotic resistancecethromycindesmethyl analoguesketolide antibioticsmolecular modelingtelithromycintotal synthesis

Identifiers

PMID24470840
PMCPMC3901159
OpenAlexW4232728248

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.