Evidence map›Paper›PMID 24470798›Full record

ArticleAdvances in urology2013

The accuracy of prostate cancer localization diagnosed on transrectal ultrasound-guided biopsy compared to 3-dimensional transperineal approach.

Kevin Krughoff, Khadijah Eid, Jason Phillips, Diliana Stoimenova, Daniel Smith, Colin O'Donnell, E David Crawford, Al Barqawi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kevin KrughoffDepartment of Surgery, Division of Urology, University of Colorado Denver School of Medicine, Academic Office One Building, Mail Stop C-319, 12631 East 17th Avenue, Room L15-5602, Aurora, CO 80045, USA.
Khadijah EidDepartment of Surgery, Division of Urology, University of Colorado Denver School of Medicine, Academic Office One Building, Mail Stop C-319, 12631 East 17th Avenue, Room L15-5602, Aurora, CO 80045, USA.
Jason PhillipsDepartment of Surgery, Division of Urology, University of Colorado Denver School of Medicine, Academic Office One Building, Mail Stop C-319, 12631 East 17th Avenue, Room L15-5602, Aurora, CO 80045, USA.
Diliana StoimenovaDepartment of Surgery, Division of Urology, University of Colorado Denver School of Medicine, Academic Office One Building, Mail Stop C-319, 12631 East 17th Avenue, Room L15-5602, Aurora, CO 80045, USA.
Daniel SmithDepartment of Surgery, Division of Urology, University of Colorado Denver School of Medicine, Academic Office One Building, Mail Stop C-319, 12631 East 17th Avenue, Room L15-5602, Aurora, CO 80045, USA.
Colin O'DonnellDepartment of Surgery, Division of Urology, University of Colorado Denver School of Medicine, Academic Office One Building, Mail Stop C-319, 12631 East 17th Avenue, Room L15-5602, Aurora, CO 80045, USA.
E David CrawfordDepartment of Surgery, Division of Urology, University of Colorado Denver School of Medicine, Academic Office One Building, Mail Stop C-319, 12631 East 17th Avenue, Room L15-5602, Aurora, CO 80045, USA.
Al BarqawiDepartment of Surgery, Division of Urology, University of Colorado Denver School of Medicine, Academic Office One Building, Mail Stop C-319, 12631 East 17th Avenue, Room L15-5602, Aurora, CO 80045, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background. Prostate cancer is often understaged following 12-core transrectal ultrasound- (TRUS-) guided biopsies. Our goal is to understand where cancers are typically missed by this method. Methods. Transperineal 3-dimensional mapping biopsy (3DMB) provides a more accurate depiction of disease status than transrectal ultrasound- (TRUS-) guided biopsy. We compared 3DMB findings in men with prior TRUS-guided biopsies to determine grade and location of missed cancer. Results were evaluated for 161 men with low-risk organ confined prostate cancer. Results. The number of cancer-positive biopsy zones per patient with TRUS was 1.38 ± 1.21 compared to 3.33 ± 4.06 with 3DMB, with most newly discovered cancers originating from the middle lobe and apex. Approximately half of all newly discovered cancerous zones resulted from anterior 3DMB sampling. Gleason upgrade was recognized in 56 patients using 3DMB. When both biopsy methods found positive cores in a given zone, Gleason upgrades occurred most frequently in the middle left and right zones. TRUS cancer-positive zones not confirmed by 3DMB were most often the basal zones. Conclusion. Most cancer upgrades and cancers missed from TRUS biopsy originated in the middle left zone of the prostate, specifically in anterior regions. Anterior sampling may lead to more accurate diagnosis and appropriate followup.

Identifiers

PMID24470798
PMCPMC3891607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.