ArticleHippokratia2013
Significance of extracapillary proliferation in IgA-nephropathy patients with regard to clinical and histopathological variables.
Article in Hippokratia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between different proportions of crescents and the progression of IgA nephropathy (IgAN): a systematic review and meta-analysis.BMC nephrology · 2024Pooled it
- Clinicopathological Analysis and Its Correlation With Various Classes of Lupus Nephritis.Cureus · 2025Article
- Review
- Divergent manifestations and outcomes of diffuse crescentic immunoglobulin A nephropathy and pauci-immune crescentic glomerulonephritis on long-term.International urology and nephrology · 2023Article
- Retrospective analysis of crescent score in clinical prognosis of IgA nephropathy.Open medicine (Warsaw, Poland) · 2022Article
- The Significance of Crescents on the Clinical Features and Outcomes of Primary Immunoglobin A Nephropathy.Frontiers in medicine · 2022Article
- Crescent lesions are not a predictive factor in adult-onset Henoch-Schönlein purpura nephritis.Clinical and experimental medicine · 2019Article
- Clinical outcomes of IgA nephropathy patients with different proportions of crescents.Medicine · 2017Observational
- Extracapillary proliferation in IgA nephropathy; recent findings and new ideas.Journal of nephropathology · 2015Review
- Association of glomerular C4d deposition with various demographic data in IgA nephropathy patients; a preliminary study.Journal of nephropathology · 2015Article
- Clinicopathological correlations in lupus nephritis; a single center experience.Journal of nephropathology · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
BACKGROUND AND
aimExtracapillary proliferation (crescent) was not included in the Oxford classification, although previous attempts to correlate the crescent with clinical outcomes have produced conflicting results. In this study, we investigated the clinical and morphological significance of extracapillary proliferation in a group of IgA nephropathy (IgAN) patients with regard to the Oxford classification. PATIENTS AND
methodsIn an observational study conducted on IgAN patients, we collected a total of 114 biopsies. We diagnosed IgAN by light and immunofluorescence for all patients.
resultsOf the 114 patients, 70.2% were male. The mean age of the patients was 37.7 ± 13.6 years. The mean proteinuria was 1742 ± 1324 mg/day. The mean serum creatinine was 1.6 ± 1.5 mg/dL. Twenty-five (21.9%) patient kidney biopsies had extracapillary proliferation. We found a significant positive correlation between the number of crescents and serum creatinine (p<0.001). Furthermore, we found a positive association between the nephrotic syndrome and the total number of crescents (p<0.05). Additionally, we observed a significant positive correlation between the amount of sclerosed glomeruli and extracapillary proliferation (p=0.028).
conclusionOur findings confirm that extracapillary proliferation has a significant association with proteinuria and sclerotic glomeruli. We anticipate that extracapillary proliferation will be included in a revision of the Oxford classification of IgAN to widen the scope of the classification.
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