Evidence map›Paper›PMID 24470550›Full record

ArticleNeuro-oncology2014

Adult pilocytic astrocytomas: clinical features and molecular analysis.

Brett J Theeler, Benjamin Ellezam, Zsila S Sadighi, Vidya Mehta, M Diep Tran, Adekunle M Adesina, Janet M Bruner, Vinay K Puduvalli

Abstract read
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In one paragraph

Article in Neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Central Nervous System Tumors in Adolescents and Young Adults.Current neurology and neuroscience reports · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Pediatric-Like Brain Tumors in Adults.Advances and technical standards in neurosurgery · 2024
    Review
  18. Astrocytoma with high-grade features and MYBL1-MMP16 fusion.Surgical neurology international · 2024
    Article
  19. Article
  20. Comparison of the clinical features and treatment outcomes of pilocytic astrocytoma in pediatric and adult patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brett J TheelerDepartment of Neurology and John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland (B.J.T.); Department of Pathology; CHU Sainte-Justine, Universite de Montreal, Montréal Quebec, Canada (B.E.); Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee (Z.S.S.); Department of Pathology, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas (V.M., M.D.T., A.M.A.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.M.B.); Department of Neurosurgery, The Ohio State University Arthur G. James Cancer Hospital, Columbus, Ohio (V.K.P.).
Benjamin EllezamDepartment of Neurology and John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland (B.J.T.); Department of Pathology; CHU Sainte-Justine, Universite de Montreal, Montréal Quebec, Canada (B.E.); Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee (Z.S.S.); Department of Pathology, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas (V.M., M.D.T., A.M.A.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.M.B.); Department of Neurosurgery, The Ohio State University Arthur G. James Cancer Hospital, Columbus, Ohio (V.K.P.).
Zsila S SadighiDepartment of Neurology and John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland (B.J.T.); Department of Pathology; CHU Sainte-Justine, Universite de Montreal, Montréal Quebec, Canada (B.E.); Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee (Z.S.S.); Department of Pathology, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas (V.M., M.D.T., A.M.A.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.M.B.); Department of Neurosurgery, The Ohio State University Arthur G. James Cancer Hospital, Columbus, Ohio (V.K.P.).
Vidya MehtaDepartment of Neurology and John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland (B.J.T.); Department of Pathology; CHU Sainte-Justine, Universite de Montreal, Montréal Quebec, Canada (B.E.); Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee (Z.S.S.); Department of Pathology, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas (V.M., M.D.T., A.M.A.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.M.B.); Department of Neurosurgery, The Ohio State University Arthur G. James Cancer Hospital, Columbus, Ohio (V.K.P.).
M Diep TranDepartment of Neurology and John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland (B.J.T.); Department of Pathology; CHU Sainte-Justine, Universite de Montreal, Montréal Quebec, Canada (B.E.); Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee (Z.S.S.); Department of Pathology, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas (V.M., M.D.T., A.M.A.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.M.B.); Department of Neurosurgery, The Ohio State University Arthur G. James Cancer Hospital, Columbus, Ohio (V.K.P.).
Adekunle M AdesinaDepartment of Neurology and John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland (B.J.T.); Department of Pathology; CHU Sainte-Justine, Universite de Montreal, Montréal Quebec, Canada (B.E.); Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee (Z.S.S.); Department of Pathology, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas (V.M., M.D.T., A.M.A.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.M.B.); Department of Neurosurgery, The Ohio State University Arthur G. James Cancer Hospital, Columbus, Ohio (V.K.P.).
Janet M BrunerDepartment of Neurology and John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland (B.J.T.); Department of Pathology; CHU Sainte-Justine, Universite de Montreal, Montréal Quebec, Canada (B.E.); Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee (Z.S.S.); Department of Pathology, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas (V.M., M.D.T., A.M.A.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.M.B.); Department of Neurosurgery, The Ohio State University Arthur G. James Cancer Hospital, Columbus, Ohio (V.K.P.).
Vinay K PuduvalliDepartment of Neurology and John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, Maryland (B.J.T.); Department of Pathology; CHU Sainte-Justine, Universite de Montreal, Montréal Quebec, Canada (B.E.); Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee (Z.S.S.); Department of Pathology, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas (V.M., M.D.T., A.M.A.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (J.M.B.); Department of Neurosurgery, The Ohio State University Arthur G. James Cancer Hospital, Columbus, Ohio (V.K.P.).

Funding

Patient Oriented Research Program in Neuro-oncologyK24CA160777 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PUDUVALLI, VINAY K · 2012 to 2015
$580k
NCI NIH HHS K24 CA160777
6 · The paper itself

Abstract

backgroundAdult pilocytic astrocytomas (PAs) are rare and have an aggressive clinical course compared with pediatric patients. Constitutive Ras/RAF/MAPK signaling appears to be an important oncogenic event in sporadic PA. We evaluated clinical data and molecular profiles of adult PAs at our institution.

methodsWe identified 127 adult PAs in our institutional database. Cases with available tissue were tested for BRAF-KIAA1549 fusion/duplication (B-K fusion) by fluorescence in situ hybridization and submitted for mutation profiling using the Sequenom mutation profiling panel. Subgroup analyses were performed based on clinical and molecular data.

resultsThe majority of adult PAs are supratentorial. Twenty-two percent of cases had an initial pathologic diagnosis discordant with the diagnosis made at our institution. Recurrence was seen in 42% of cases, and 13% of patients died during follow-up. Adjuvant radiotherapy following surgical resection was associated with a statistically significant decrease in progression-free survival (P = .004). B-K fusion was identified in 20% (9 of 45) of patients but was not associated with outcome. No BRAF V600E mutations (0 of 40 tested) were found.

conclusionThis was the largest single institution series of adult PA. A significant proportion of adult PAs follow an aggressive clinical course. Our results support a period of observation following biopsy or surgical resection. B-K fusion in adult PA does not influence outcome, and BRAF V600E mutation appears to be a very rare event. Further study of tumor biology and optimal treatment is needed, given a more aggressive clinical behavior.

Indexed as

AdolescentAdultAgedAstrocytomaBrain NeoplasmsFemaleHumansMaleMiddle AgedMutationOncogene Proteins, FusionTreatment OutcomeYoung AdultBRAF-KIAA1549 fusion protein, humanOncogene Proteins, FusionBRAF mutationlow-grade astrocytomapilocytic astrocytoma

Identifiers

PMID24470550
PMCPMC4022218

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.