Evidence map›Paper›PMID 24470291›Full record

ReviewContrast media & molecular imaging

Multicolor computed tomographic molecular imaging with noncrystalline high-metal-density nanobeacons.

Dipanjan Pan, Carsten O Schirra, Samuel A Wickline, Gregory M Lanza

Abstract readReview
In one paragraph

Review in Contrast media & molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. An unmet clinical need: The history of thrombus imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Review
  10. Article
  11. Review
  12. Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dipanjan PanDepartment of Medicine, Washington University School of Medicine, St Louis, MO, 63108, USA.
Carsten O Schirra
Samuel A Wickline
Gregory M Lanza

Funding

METHODS IN MOLECULAR IMAGING AND TARGETED THERAPEUTICSR01HL073646 · NHLBI · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2004 to 2016
$13.7M
Task Specific Project 3: Diffuse Optical TomographyU54CA136398 · NCI · WASHINGTON UNIVERSITY · PI WANG, LIHONG · 2008 to 2012
$6.0M
Theranostic Approach to Asthma Using Anti-Angiogenic NanomedicineR01HL113392 · NHLBI · WASHINGTON UNIVERSITY · PI LANZA, GREGORY M, WAGNER, ELIZABETH · 2012 to 2016
$3.3M
Characterization/bioinformatics-modeling of nanoparticle:complement interactionsU01NS073457 · NINDS · WASHINGTON UNIVERSITY · PI HOURCADE, DENNIS EMIL · 2010 to 2012
$3.0M
NEXT GENERATION APPROACHES TO BREAST CANCER USING IMAGE GUIDED DRUG DELIVERYR01CA154737 · NCI · WASHINGTON UNIVERSITY · PI LANZA, GREGORY M, PAN, DIPANJAN · 2011 to 2015
$2.4M
Fibrin-Specific Thrombolytic Nanoparticles for Acute StrokeR01NS059302 · NINDS · WASHINGTON UNIVERSITY · PI LANZA, GREGORY M · 2007 to 2011
$1.7M
TARGETED NANOTHERAPY IN THE TREATMENT OF INFLAMMATORY ARTHRITISR01AR056468 · NIAMS · WASHINGTON UNIVERSITY · PI PHAM, CHRISTINE T. · 2008 to 2012
$1.6M
Targeted Nanoparticles of Bismuth Organo Complexes for Spectral CT Imaging of CorR42HL112518 · NHLBI · OCEAN NANOTECH, LLC · PI LANZA, GREGORY M, WANG, YONGQIANG ANDREW · 2012 to 2015
$1.4M
NCI NIH HHS R01 CA154737NCI NIH HHS U54 CA136398NHLBI NIH HHS R01 HL073646NHLBI NIH HHS R01 HL113392NHLBI NIH HHS R42 HL112518NIAMS NIH HHS R01 AR056468NINDS NIH HHS R01 NS059302NINDS NIH HHS U01 NS073457
6 · The paper itself

Abstract

Computed tomography (CT) is one of the most frequently pursued radiology technologies applied in the clinics today and in the preclinical field of biomedical imaging. Myriad advances have been made to make this technique more powerful with improved signal sensitivity, rapid image acquisition and faster reconstruction. Synergistic development of novel nanoparticles has been adopted to produce the next-generation CT contrasts agents for imaging specific biological markers. Nanometer-sized agents are anticipated to play a critical part in the prospect of medical diagnostics owing to their capabilities of targeting specific biological markers, extended blood circulation time and defined biological clearance. This review paper introduces the readers to the fundamental design principles of nanoparticulate CT contrast agents with a special emphasis on molecular imaging with noncrystalline high-metal-density nanobeacons.

Indexed as

Contrast MediaMetal NanoparticlesBiomarkersHumansMolecular ImagingTomography, X-Ray ComputedBiomarkersContrast Mediaangiogenesisbismuthcomputed tomographic imagingfibringoldiodinenanoparticlesentinel lymph nodetantalumthrombusytterbium

Identifiers

PMID24470291
PMCPMC4076970

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.