ArticleJournal of neurovirology2014
Detrimental impact of remote methamphetamine dependence on neurocognitive and everyday functioning in older but not younger HIV+ adults: evidence for a legacy effect?
Article in Journal of neurovirology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Abbreviated Goal Management Training Shows Preliminary Evidence as a Neurorehabilitation Tool for HIV-associated Neurocognitive Disorders among Substance Users.The Clinical neuropsychologist · 2016Trial
- Examining Age as Moderating Associations Between Methamphetamine Abstinence and Cognitive Function in People with HIV.Viruses · 2026Article
- A History of Methamphetamine Use Disorder in People with HIV Is Associated with Altered Functional Response to Risky Choice.Viruses · 2026Article
- Clinical outcomes of ocular syphilis within the Great Plains region: potential syndemic impact of methamphetamine use.Eye (London, England) · 2025Observational
- Article
- Ageing and older people who use illicit opioids, cocaine or methamphetamine: a scoping review and literature map.Addiction (Abingdon, England) · 2022Article
- Prior Methamphetamine Use Disorder History Does Not Impair Interoceptive Processing of Soft Touch in HIV Infection.Viruses · 2021Article
- Conceptualizing and Assessing Everyday Functioning in the Context of HIV-Associated Neurocognitive Disorders.Current topics in behavioral neurosciences · 2021Review
- Methamphetamine and Cannabis: A Tale of Two Drugs and their Effects on HIV, Brain, and Behavior.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- HIV Neuropathogenesis in the Presence of a Disrupted Dopamine System.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- The impact of substance abuse on HIV-mediated neuropathogenesis in the current ART era.Brain research · 2019Review
- Redefining Aging in HIV Infection Using Phenotypes.Current HIV/AIDS reports · 2017Review
- Everyday functional ability in HIV and methamphetamine dependence.Drug and alcohol dependence · 2017Article
- Accelerated and accentuated neurocognitive aging in HIV infection.Journal of neurovirology · 2017Article
- Effects of HIV and Methamphetamine on Brain and Behavior: Evidence from Human Studies and Animal Models.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Review
- The impact of age, HIV serostatus and seroconversion on methamphetamine use.The American journal of drug and alcohol abuse · 2016Article
- HIV-1, methamphetamine and astrocytes at neuroinflammatory Crossroads.Frontiers in microbiology · 2015Review
- A history of alcohol dependence augments HIV-associated neurocognitive deficits in persons aged 60 and older.Journal of neurovirology · 2014Article
- Recent cocaine use and memory impairment in HIV.Applied neuropsychology. AdultArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Prior studies examining the combined adverse effects of HIV and methamphetamine (MA) on the central nervous system (CNS) have focused on younger to middle-aged adults with recent MA use diagnoses. Aging, HIV, and MA all converge on prefrontal and temporolimbic neural systems and confer independent risk for neurocognitive and functional decline. Thus, this study sought to determine the residual impact of a remote history of MA dependence on neurocognitive and real-world outcomes in older people living with HIV (PLWH). Participants included 116 older (≥50 years) and 94 younger (<40 years) adults classified into one of six study groups based on HIV serostatus (HIV+/HIV-) and lifetime histories of MA dependence (MA+/MA-): older HIV-MA- (n = 36), older HIV+MA- (n = 49), older HIV+MA+ (n = 31), younger HIV-MA- (n = 27), younger HIV+MA- (n = 33), and younger HIV+MA+ (n = 34). No participant-met criteria for current MA use disorders and histories of MA dependence were remote in both the older (average of nearly 9 years prior to evaluation) and younger (average of over 2 years prior to evaluation) HIV+MA+ groups. Findings revealed that a remote history of MA dependence exerts a significant detrimental impact on specific aspects of neurocognitive performance (e.g., memory) and a broad range of real-world functioning outcomes (e.g., employment) among older, but not younger PLWH. These results suggest that MA-associated neurotoxicity may have significant "legacy" effects on both neurocognitive and functional outcomes to which older PLWH are particularly vulnerable.
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