Evidence map›Paper›PMID 24470204›Full record

ReviewCurrent hypertension reports2014

Is there a role for the incretin system in blood pressure regulation?

Akhilesh Rao, Ravi Nistala

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hypertension reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Risk Factors in Adolescent Hypertension.Global pediatric health · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Akhilesh RaoDivision of Nephrology, Department of Internal Medicine, University of Missouri-Columbia School of Medicine, 5 Hospital Drive, Columbia, MO, 65212, USA.
Ravi Nistala
University of Missouri Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Incretin-based therapies are now well established for diabetes management and are among the frontline agents for control of hyperglycemia. In addition to their antihyperglycemic effects, evidence is emerging on the role of these agents on blood pressure regulation, cardioprotective and renoprotective properties. Because of the pleiotropic nature of these affects, these agents could offer significant benefits with regards to the cardiorenal metabolic complications that are part of the diabetes and obesity epidemic in the United States and worldwide. We review the various known mechanisms or pathways by which incretin based therapy exerts its regulation of blood pressure with emphasis on novel mechanisms such as inflammation/immunomodulation and oxidative stress.

Indexed as

AnimalsBlood PressureDipeptidyl-Peptidase IV InhibitorsExenatideGlucagon-Like Peptide 1HumansHypertensionIncretinsOxidative StressPeptidesPyrazinesRenin-Angiotensin SystemSitagliptin PhosphateT-Lymphocytes, RegulatoryTriazolesVenomsDipeptidyl-Peptidase IV InhibitorsExenatideGlucagon-Like Peptide 1IncretinsPeptidesPyrazinesSitagliptin PhosphateTriazolesVenoms

Identifiers

PMID24470204
OpenAlexW1990539525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.