ArticlePsychosomatic medicine2014
The association between major depressive disorder in childhood and risk factors for cardiovascular disease in adolescence.
Article in Psychosomatic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- The relationship between screen-based sedentary behaviors and symptoms of depression and anxiety in youth: a systematic review of moderating variables.BMC public health · 2020Pooled it
- A 6-Month Open-Label Extension Study of Vortioxetine in Pediatric Patients with Depressive or Anxiety Disorders.Journal of child and adolescent psychopharmacology · 2018Trial
- Identifying Cardiovascular Disease Risk Endotypes of Adolescent Major Depressive Disorder Using Exploratory Unsupervised Machine Learning.JAACAP open · 2025Article
- Association of mental health in childhood, adolescence and young adulthood with cardiovascular risk factors and carotid remodeling below age 30 - results from the KiGGS cohort study.European journal of epidemiology · 2025Article
- Depressive Symptoms, Antidepressants, and Clinical Outcomes in Chronic Kidney Disease: Findings from the CRIC Study.Kidney medicine · 2024Article
- Perceived Neighborhood Social Environment and Adolescent Depressive Symptoms: Insights from the Add Health.Health equity · 2024Article
- Psychiatric Disorders and Obesity in Childhood and Adolescence-A Systematic Review of Cross-Sectional Studies.Children (Basel, Switzerland) · 2023Review
- Adverse Childhood Experiences and Cardiovascular Health: An Exploration of Protective Social Determinants Among Young Adult Black Women.ANS. Advances in nursing science · 2022Article
- Adiposity and Smoking Mediate the Relationship Between Depression History and Inflammation Among Young Adults.International journal of behavioral medicine · 2022Article
- Review
- Childhood-onset depression and arterial stiffness in young adulthood.Journal of psychosomatic research · 2021Article
- Cardiovascular Disease Risk Factors Among Children and Adolescents With Depression.Frontiers in psychiatry · 2021Article
- Voice perturbations under the stress overload in young individuals: phenotyping and suboptimal health as predictors for cascading pathologies.The EPMA journal · 2020Article
- Psychological symptoms are associated with screen and exercise time: a cross-sectional study of Chinese adolescents.BMC public health · 2020Article
- Obesity and Depression: Its Prevalence and Influence as a Prognostic Factor: A Systematic Review.Psychiatry investigation · 2020Article
- Cardiac vagal control mediates the relation between past depression and blood pressure several years later among young adults.Psychophysiology · 2020Article
- Reciprocal associations between depression and screen-based sedentary behaviors in adolescents differ by depressive symptom dimension and screen-type.Journal of affective disorders · 2020Article
- Lifestyles and Cardiovascular Prevention in Childhood and Adolescence.Pediatric cardiology · 2019Review
- Associations of depression severity with heart rate and heart rate variability in young adults across normative and clinical populations.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2019Article
- A student-centered intervention program to educate and retain knowledge in stroke education and healthy habits.Preventive medicine reports · 2019Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
objectiveDepression in adults is associated with risk factors for cardiovascular disease (CVD). It is unclear, however, when the association between clinical depression and cardiac risk factors develops or how early in life this association can be detected.
methodsIn an ongoing study of pediatric depression, we compared CVD risk factors including smoking, obesity, physical activity level, sedentary behavior, and parental history of CVD across three samples of adolescents: probands with established histories of childhood-onset major depressive disorder (n = 210), never-depressed siblings of probands (n = 195), and controls with no history of any major psychiatric disorder (n = 161).
resultsWhen assessed during adolescence, 85% of the probands were not in a major depressive episode. Nevertheless, at that assessment, probands had a higher prevalence of regular smoking (odds ratio [OR] = 12.54, 95% confidence interval [CI] = 4.36-36.12) and were less physically active than controls (OR = 0.59, CI = 0.43-0.81) and siblings (OR = 0.70, CI = 0.52-0.94) and had a higher rate of obesity than did controls (OR = 3.67, CI = 1.42-9.52). Parents of probands reported high rates of CVD (significantly higher than did parents of controls), including myocardial infarction and CVD-related hospitalization (ORs = 1.62-4.36, CIs = 1.03-15.40). Differences in CVD risk factors between probands and controls were independent of parental CVD.
conclusionsMajor depression in childhood is associated with an unfavorable CVD risk profile in adolescence, and risks for pediatric depression and CVD may coincide in families. Effective prevention and treatment of childhood depression may be a means to reduce the incidence of adult CVD.
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Registered trials
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