ReviewMetal ions in life sciences2013
Manganese in health and disease.
Review in Metal ions in life sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
147 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Metal coordination at biological interfaces: Mechanisms, therapeutics, and translation.Materials today. Bio · 2026Review
- Identification of Molecular Pathways Underlying Mn(II) Oxidation in Pseudomonas resinovorans.Environmental microbiology · 2026Article
- An integrated experimental and computational systems biology analysis reveals molecular mechanisms underlying reproductive toxicity induced by manganese and atrazine.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Harnessing eco-friendly synthesis: the in vitro bioactivity and biocompatibility of ceramic spinels.Scientific reports · 2026Article
- Essential Trace Elements in Commonly Consumed Varieties of Sri Lankan Cooked Rice and its Dietary Significance: A Focus on Recommended Daily Allowances.Biological trace element research · 2026Article
- Mineral and heavy metal content in canned tuna: Implications for veterinary public health and consumer safety.Veterinary research communications · 2026Article
- Paper-Based Microfluidics Platform for Enhanced On-Site Electrochemical Detection of Manganese in Water.ACS omega · 2026Article
- Dysregulation of Trace Elements in Pediatric Cholestasis: From Pathophysiology to Nutritional Approaches.International journal of molecular sciences · 2026Review
- Disrupted Tryptophan Metabolism Mediates Manganese-Induced Neurogenesis and Neuroinflammatory Impairments: Rescue by Exogenous Melatonin.Environment & health (Washington, D.C.) · 2026Article
- Neurotoxic Effect of Manganese and Vanadium Co-Exposure in Animal Models of Parkinson's Disease.International journal of molecular sciences · 2026Article
- Optimization of protein extraction and digestion workflows for proteomic analysis of saliva, salivary stones and kidney stones.Frontiers in molecular biosciences · 2026Article
- Metal-Based Therapeutic Approaches for Overcoming Cancer Drug Resistance: Mechanisms, Drug Delivery Strategies, and Clinical Perspectives.Oncology research · 2026Review
- Extracellular Vesicles, Nutrient Balance, and Redox Metabolism During Epididymal Sperm Maturation: A Perspective on the Complexity of Intercellular Interplay.Advances in anatomy, embryology, and cell biology · 2026Review
- Heavy Metals Like Aluminum, Arsenic, Cadmium, Chromium, Copper, Iron, Lead, Manganese, Mercury, Nickel, and Zinc Polluting the Drinking Water: Their Individual Health Hazards.International journal of molecular sciences · 2025Review
- Source apportionment, ecological and human health risk assessment of potentially toxic elements in Tumet River, Ethiopia.Toxicology reports · 2025Article
- Removal of Toxic Metabolites-Chelation: Manganese Disorders.Journal of inherited metabolic disease · 2025Review
- Consequences of Dietary Manganese Deficiency or MnNutrients · 2025Article
- Manganese Neurotoxicity and Familial Disorders of Manganese Transport.Annals of the Child Neurology Society · 2025Review
- Prenatal exposure to manganese and objectively measured sleep disturbances in early childhood.Environmental research · 2025Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Hence, Mn has a paradoxal effect in animals, a Janus-faced metal. Extensive work has been carried out to understand Mn-induced neurotoxicity and to find an effective treatment. This review focuses on the requirement for Mn in human health as well as the diseases associated with excessive exposure to this metal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.