ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
Prevalence, location, and extent of significant coronary artery disease in patients with normal myocardial perfusion imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Left main coronary artery stenosis presenting with negative myocardial perfusion imaging: a case report of balanced ischaemia.European heart journal. Case reports · 2025Article
- The Role of Cardiac PET in Diagnosis and Prognosis of Ischemic Heart Disease: Optimal Modality Across Different Patient Populations.Current atherosclerosis reports · 2023Review
- Feasibility and accuracy of SPECT myocardial perfusion imaging in end-stage lung disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Predictors of severe stenosis at invasive coronary angiography in patients with normal myocardial perfusion imaging.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2018Article
- Reconciling discordant myocardial perfusion imaging and coronary angiography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Review
- Multi-vessel disease and CZT SPECT. Comparison with coronary angiography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Uncertainty of Myocardial Perfusion Imaging in Chest Pain Risk Stratification.Ochsner journal · 2017Article
- Review of cardiovascular imaging in The Journal of Nuclear Cardiology in 2014: Part 2 of 2: Myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- Diastolic dysfunction and endothelial dysfunction in systemic lupus erythematosus.Rheumatology international · 2015Article
- Noninvasive Fractional Flow Reserve for the Diagnosis of Lesion-specific Ischemia: A Case Example.Journal of clinical imaging science · 2015Article
- Anatomy vs physiology: is that the question?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundFalse-negative myocardial perfusion imaging (MPI) can by due to left main (LM) or three-vessel disease causing "balanced ischemia". However, so far prevalence of LM or three-vessel-disease in patients with normal MPI is unclear. We assessed prevalence, location, and extent of significant coronary artery disease (CAD) in patients with normal MPI.
methodsBetween 2006 and 2010, 256 patients with normal MPI who had invasive angiography because of persisting or worsening of the same initial symptoms were studied. Significant CAD was defined as stenosis > 70% or LM > 50%.
resultsA total of 93 patients (36%) had significant CAD. Significant CAD was observed more frequently in males, higher age and those with typical angina complaints. Significant LM disease was present in 7%, three-vessel disease in 10%, two-vessel disease in 22%, and single vessel disease (not left main) in 61%. In those with single vessel disease, the location was the LAD in 40%, the RCA in 30%, and the LCX in 30%.
conclusionsIn selected patients with normal MPI, one-third had significant CAD. The majority of these patients had single vessel disease (not left main). LM or three vessel disease, causing "balanced ischemia", is a less common cause of false-negative MPI.
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