ArticleProceedings of the National Academy of Sciences of the United States of America2014
Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers, 1 of them a synthesis that pooled it.
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Who cites it
235 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Environmental palaeogenomic reconstruction of an Ice Age algal population.Communications biology · 2021Pooled it
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- Ancient wheat DNA: How and what for?Journal, genetic engineering & biotechnology · 2026Article
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- DNA signatures preserved in the official 1978 sample collection of the Shroud of Turin.Scientific reports · 2026Article
- Multidisciplinary Exploration of Computed-Tomographic and Ancient-DNA Data of an Iron Age Skull From Latvia With Multiple Lytic Bone Lesions: Differential Diagnosis Between Metastatic Carcinoma, Multiple Myeloma and Skeletal Tuberculosis.Ecology and evolution · 2026Article
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- The genetic landscape of northeastern Iberian communities from the early to late Iron Age.iScience · 2026Article
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- The Iceman's microbiome: unveiling millennia of microbial diversity and continuity.Microbiome · 2026Article
- Multiple Genetic Shifts at the Crossroads of the Eastern Steppe and Loess Plateau Over 4,000 Years.Nature communications · 2026Article
- First Lithic Age Caribbean genomes document pre-Ceramic genetic continuity and affinities to Central America and northern South America.bioRxiv : the preprint server for biology · 2026Article
- FALCON2: compression-based metagenomic classification of ancient viruses.Bioinformatics (Oxford, England) · 2026Article
- Insights into human adaptation from ancient DNA.Nature genetics · 2026Review
- Optimal Reference Panel Design in Ancient DNA Imputation from Coalescent Theory, Simulation, and Real Data Application with an Ancient Reference Panel.bioRxiv : the preprint server for biology · 2026Article
- Archaeogenetic insights into the demographic history of Late Neanderthals.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Analysis of medieval burials from Ibiza reveals genetic and pathogenic diversity during the Islamic period.Nature communications · 2026Article
- Uncovering a Medieval Pogrom: Genetic History of a Jewish Community in Catalonia (Spain).Genes · 2026Article
- Ancient genomes reveal the genetic history of domestic goats on the Qinghai-Xizang Plateau approximately 3 600 years ago.Zoological research · 2026Article
175 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
One of the main impediments for obtaining DNA sequences from ancient human skeletons is the presence of contaminating modern human DNA molecules in many fossil samples and laboratory reagents. However, DNA fragments isolated from ancient specimens show a characteristic DNA damage pattern caused by miscoding lesions that differs from present day DNA sequences. Here, we develop a framework for evaluating the likelihood of a sequence originating from a model with postmortem degradation-summarized in a postmortem degradation score-which allows the identification of DNA fragments that are unlikely to originate from present day sources. We apply this approach to a contaminated Neandertal specimen from Okladnikov Cave in Siberia to isolate its endogenous DNA from modern human contaminants and show that the reconstructed mitochondrial genome sequence is more closely related to the variation of Western Neandertals than what was discernible from previous analyses. Our method opens up the potential for genomic analysis of contaminated fossil material.
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