ArticleMolecular and cellular biology2014
Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development.
Article in Molecular and cellular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- gdf11 is required for pronephros/cloaca development through targeting TGF-β signaling.Scientific reports · 2025Article
- Male germ cell-associated kinase is required for axoneme formation during ciliogenesis in zebrafish photoreceptors.Disease models & mechanisms · 2024Article
- Rare variants found in multiplex families with orofacial clefts: Does expanding the phenotype make a difference?American journal of medical genetics. Part A · 2023Article
- Transcriptome-Wide Regulation of Key Developmental Pathways in the Mouse Neural Tube by Prenatal Alcohol Exposure.Alcoholism, clinical and experimental research · 2020Article
- Septins in kidney: A territory little explored.Cytoskeleton (Hoboken, N.J.) · 2019Review
- TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway.Circulation · 2018Article
- A Soft Microenvironment Protects from Failure of Midbody Abscission and Multinucleation Downstream of the EMT-Promoting Transcription Factor Snail.Cancer research · 2018Article
- Use of zebrafish to studyDisease models & mechanisms · 2018Review
- Depletion of Tissue-Specific Ion Transporters Causes Differential Expression of PRL Targets in Response to Increased Levels of Endogenous PRL.Frontiers in endocrinology · 2018Article
- Folate-dependent methylation of septins governs ciliogenesis during neural tube closure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Septins restrict inflammation and protect zebrafish larvae from Shigella infection.PLoS pathogens · 2017Article
- From Planar Cell Polarity to Ciliogenesis and Back: The Curious Tale of the PPE and CPLANE proteins.Trends in cell biology · 2017Review
- Uncovering the Roles of Septins in Cilia.Frontiers in cell and developmental biology · 2017Review
- Expression ofFrontiers in neuroanatomy · 2017Article
- The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation.Oncotarget · 2016Article
- Asymmetric Distribution of Primary Cilia Allocates Satellite Cells for Self-Renewal.Stem cell reports · 2016Article
- Visualization of in vivo septin ultrastructures by platinum replica electron microscopy.Methods in cell biology · 2016Article
- Kupffer's vesicle size threshold for robust left-right patterning of the zebrafish embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Orphan G-protein coupled receptor 22 (Gpr22) regulates cilia length and structure in the zebrafish Kupffer's vesicle.PloS one · 2014Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Septins are conserved filament-forming GTP-binding proteins that act as cellular scaffolds or diffusion barriers in a number of cellular processes. However, the role of septins in vertebrate development remains relatively obscure. Here, we show that zebrafish septin 6 (sept6) is first expressed in the notochord and then in nearly all of the ciliary organs, including Kupffer's vesicle (KV), the pronephros, eye, olfactory bulb, and neural tube. Knockdown of sept6 in zebrafish embryos results in reduced numbers and length of cilia in KV. Consequently, cilium-related functions, such as the left-right patterning of internal organs and nodal/spaw signaling, are compromised. Knockdown of sept6 also results in aberrant cilium formation in the pronephros and neural tube, leading to cilium-related defects in pronephros development and Sonic hedgehog (Shh) signaling. We further demonstrate that SEPT6 associates with acetylated α-tubulin in vivo and localizes along the axoneme in the cilia of zebrafish pronephric duct cells as well as cultured ZF4 cells. Our study reveals a novel role of sept6 in ciliogenesis during early embryonic development in zebrafish.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.