Evidence map›Paper›PMID 24469236›Full record

ReviewShock (Augusta, Ga.)2014

Reducing the burden of acute respiratory distress syndrome: the case for early intervention and the potential role of the emergency department.

Brian M Fuller, Nicholas M Mohr, Richard S Hotchkiss, Marin H Kollef

Abstract readReview
In one paragraph

Review in Shock (Augusta, Ga.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Article
  3. Strategies to DAMPen COVID-19-mediated lung and systemic inflammation and vascular injury.Translational research : the journal of laboratory and clinical medicine · 2021
    Review
  4. Article
  5. ALVEOLAR RECRUITMENT MANEUVERS FOR CHILDREN WITH CANCER AND ACUTE RESPIRATORY DISTRESS SYNDROME: A FEASIBILITY STUDY.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2021
    Article
  6. Article
  7. Observational
  8. Article
  9. Review
  10. Observational
  11. Observational
  12. Observational
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brian M Fuller*Divisions of Critical Care and Emergency Medicine, Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri; †Departments of Emergency Medicine and Anesthesiology, Division of Critical Care Roy J. and Lucille A. Carver College of Medicine, University of Iowa; ‡Division of Critical Care, Department of Anesthesiology, and §Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri.
Nicholas M Mohr
Richard S Hotchkiss
Marin H Kollef

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Institute of Clinical and Translational SciencesKL2TR000450 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$8.8M
Prevention of Apoptotic Cell Death in Sepsis by BCL-2R37GM044118 · NIGMS · WASHINGTON UNIVERSITY · PI HOTCHKISS, RICHARD SAMUEL · 2003 to 2012
$5.1M
CELLULAR MECHANISMS OF SEPSIS AND ORGAN FAILURER01GM055194 · NIGMS · WASHINGTON UNIVERSITY · PI HOTCHKISS, RICHARD SAMUEL · 1997 to 2012
$4.7M
PREVENTION OF APOPTOTIC CELL DEATH IN SEPSIS BY BCL-2R01GM044118 · NIGMS · WASHINGTON UNIVERSITY · PI HOTCHKISS, RICHARD SAMUEL · 1992 to 2017
$2.7M
NCATS NIH HHS KL2 TR000450NCATS NIH HHS UL1 TR000448NIGMS NIH HHS GM 44118NIGMS NIH HHS GM 55194NIGMS NIH HHS R01 GM044118NIGMS NIH HHS R01 GM055194NIGMS NIH HHS R37 GM044118
6 · The paper itself

Abstract

The mortality for acute respiratory distress syndrome (ARDS) remains unacceptably high. Success in clinical trials has been limited, resulting in a lack of effective therapies to treat the syndrome. The projected increase in mechanically ventilated patients and global need for critical care services suggests that the clinical and research landscape in ARDS can no longer be confined to the intensive care unit. A demonstrable minority of patients present to the emergency department (ED) with ARDS, and ARDS onset typically occurs shortly after intensive care unit admission. Furthermore, the ED is an entry point for many of the highest-risk patients for ARDS development and progression. These facts, combined with prolonged lengths of stay in the ED, suggest that the ED could represent a window of opportunity for treatment and preventive strategies, as well as clinical trial enrollment. This review aims to discuss some of the potential strategies that may prevent or alter the trajectory of ARDS, with a focus on the potential role the ED could play in reducing the burden of this syndrome.

Indexed as

Emergency Service, HospitalHumansIntensive Care UnitsRespiration, ArtificialRespiratory Distress Syndrome

Identifiers

PMID24469236
PMCPMC4108587

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.