Evidence map›Paper›PMID 24469034›Full record

ArticleOncogene2015

Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment.

A Savar, S Acin, C L Gonzalez, T El-Sawy, O Mejia, Z Li, B Esmaeli, A Lacy-Hulbert, A K El-Naggar, J H McCarty and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Deletion of p53 and Hyper-Activation of PIK3CA in Keratin-15International journal of molecular sciences · 2020
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Kindler syndrome in mice and men.Cancer biology & therapy · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

A SavarDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
S AcinDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
C L GonzalezDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
T El-SawyDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
O MejiaDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Z LiDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
B EsmaeliDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
A Lacy-HulbertDepartment of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.
A K El-NaggarDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
J H McCartyDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
C Caulin1] Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA [2] Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
The University of Texas MD Anderson Cancer Center · USMassachusetts General Hospital · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Deciphering mechanisms of perivascular tumor cell invasion in glioblastomaR01NS078402 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MCCARTY, JOSEPH H · 2012 to 2016
$1.9M
Inductible mouse models for oral cancerR01DE015344 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CAULIN, CARLOS · 2005 to 2009
$1.8M
NCI NIH HHS CA16672NCI NIH HHS P30 CA016672NIDCR NIH HHS DE015344NIDCR NIH HHS R01 DE015344NINDS NIH HHS R01 NS078402
6 · The paper itself

Abstract

Most of the squamous cell carcinomas (SCCs) of the skin and head and neck contain p53 mutations. The presence of p53 mutations in premalignant lesions suggests that they represent early events during tumor progression and additional alterations may be required for SCC development. Here we show that codeletion of the p53 and αv integrin genes in mouse stratified epithelia induced SCCs in 100% of the mice, more frequently and with much shorter latency than deletion of either gene alone. The SCCs that lacked p53 and αv in the epithelial tumor cells exhibited high Akt activity, lacked multiple types of infiltrating immune cells, contained a defective vasculature and grew slower than tumors that expressed p53 or αv. These results reveal that loss of αv in epithelial cells that lack p53 promotes SCC development, but also prevents remodeling of the tumor microenvironment and delays tumor growth. We observed that Akt inactivation in SCC cells that lack p53 and αv promoted anoikis. Thus, tumors may arise in these mice as a result of the increased cell survival induced by Akt activation triggered by loss of αv and p53, and by the defective recruitment of immune cells to these tumors, which may allow immune evasion. However, the defective vasculature and lack of a supportive stroma create a restrictive microenvironment in these SCCs that slows their growth. These mechanisms may underlie the rapid onset and slow growth of SCCs that lack p53 and αv.

Indexed as

Tumor MicroenvironmentAnimalsCarcinoma, Squamous CellIntegrin alphaVMAP Kinase Signaling SystemMiceMouth NeoplasmsProto-Oncogene Proteins c-aktSkin NeoplasmsTumor Suppressor Protein p53Integrin alphaVProto-Oncogene Proteins c-aktTumor Suppressor Protein p53

Identifiers

PMID24469034
PMCPMC4303549
OpenAlexW2005709666

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.