Evidence map›Paper›PMID 24468878›Full record

ReviewNature reviews. Neurology2014

Disorders of consciousness after acquired brain injury: the state of the science.

Joseph T Giacino, Joseph J Fins, Steven Laureys, Nicholas D Schiff

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 359 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
359citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02644265 unknown statusnot on this mapstarted 2017, after this paper: background citation

CONNECT-ME: CONsciousness in NEurocritical Care cohorT Study Using fMRI and EEG

Typeobservational_patient_registrySponsorRigshospitalet, DenmarkRan2017 to 2025Enrolled100ConditionsAcute Brain Injuries, Consciousness Disorders
NCT03826407 unknown statusnot on this mapstarted 2019, after this paper: background citation

Development of a Point of Care System for Automated Coma Prognosis - A Prospective Cohort Study

TypeobservationalSponsorMcMaster UniversityRan2019 to 2023Enrolled33ConditionsComa, Disorder of Consciousness, Minimally Conscious State, Vegetative State
3 · Its place in the literature

Who cites it

359 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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299 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joseph T GiacinoDepartment of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, 300 First Avenue, Charlestown, Boston, MA 02129, USA.
Joseph J FinsDivision of Medical Ethics, Weill Cornell Medical College, 435 East 70th Street, Suite 4-J, New York, NY 10021, USA.
Steven LaureysComa Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, Sart Tilman B30, 4000 Liège, Belgium.
Nicholas D SchiffFeil Family Brain and Mind Research Institute, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

Funding

PHS HHS H133A120085
6 · The paper itself

Abstract

The concept of consciousness continues to defy definition and elude the grasp of philosophical and scientific efforts to formulate a testable construct that maps to human experience. Severe acquired brain injury results in the dissolution of consciousness, providing a natural model from which key insights about consciousness may be drawn. In the clinical setting, neurologists and neurorehabilitation specialists are called on to discern the level of consciousness in patients who are unable to communicate through word or gesture, and to project outcomes and recommend approaches to treatment. Standards of care are not available to guide clinical decision-making for this population, often leading to inconsistent, inaccurate and inappropriate care. In this Review, we describe the state of the science with regard to clinical management of patients with prolonged disorders of consciousness. We review consciousness-altering pathophysiological mechanisms, specific clinical syndromes, and novel diagnostic and prognostic applications of advanced neuroimaging and electrophysiological procedures. We conclude with a provocative discussion of bioethical and medicolegal issues that are unique to this population and have a profound impact on care, as well as raising questions of broad societal interest.

Indexed as

Consciousness DisordersBrain InjuriesHumansNeuroimagingNeurophysiology

Identifiers

PMID24468878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.