Evidence map›Paper›PMID 24468824›Full record

ArticleMolecular psychiatry2015

Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci.

O A Andreassen, H F Harbo, Y Wang, W K Thompson, A J Schork, M Mattingsdal, V Zuber, F Bettella, S Ripke, J R Kelsoe and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 1 pooled it
21.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 1 synthesis or guideline pooled it, 213 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. The future of diagnosis in clinical neurosciences: Comparing multiple sclerosis and schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2023
    Review
  15. Article
  16. Review
  17. Fecal Microbiota Underlying the Coexistence of Schizophrenia and Multiple Sclerosis in Chinese Patients.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Article
  18. The Influence of HLA Alleles on the Affective Distress Profile.International journal of environmental research and public health · 2022
    Article
  19. The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022
    Article
  20. Article

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 3 countries.

O A Andreassen1] NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway [2] Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway [3] Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
H F HarboDepartment of Neurology, Oslo University Hospital, Ullevål, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Y Wang1] NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway [2] Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway [3] Multimodal Imaging Laboratory, University of California at San Diego, La Jolla, CA, USA [4] Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
W K ThompsonDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
A J Schork1] Multimodal Imaging Laboratory, University of California at San Diego, La Jolla, CA, USA [2] Cognitive Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA [3] Center for Human Development, University of California at San Diego, La Jolla, CA, USA.
M Mattingsdal1] NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway [2] Sørlandet Hospital, Kristiansand, Norway.
V Zuber1] NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway [2] Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway [3] Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway.
F Bettella1] NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway [2] Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
S Ripke1] Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA [2] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
J R KelsoeDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
K S KendlerVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
M C O'DonovanMRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.
P SklarThe Division of Psychiatric Genetics and Genomics, Mount Sinai School of Medicine, New York, NY, USA.
Psychiatric Genomics Consortium (PGC) Bipolar Disorder and Schizophrenia Work Groups
International Multiple Sclerosis Genetics Consortium (IMSGC)
L K McEvoy1] Multimodal Imaging Laboratory, University of California at San Diego, La Jolla, CA, USA [2] Department of Radiology, University of California, San Diego, La Jolla, CA, USA.
R S Desikan1] Multimodal Imaging Laboratory, University of California at San Diego, La Jolla, CA, USA [2] Department of Radiology, University of California, San Diego, La Jolla, CA, USA.
B A LieDepartment of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.
S Djurovic1] NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway [2] Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway [3] Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.
A M Dale1] Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA [2] Multimodal Imaging Laboratory, University of California at San Diego, La Jolla, CA, USA [3] Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA [4] Department of Radiology, University of California, San Diego, La Jolla, CA, USA.
University of California, San Diego · USUniversity of Oslo · NOOslo University Hospital · NOBroad Institute · USCardiff University · GBIcahn School of Medicine at Mount Sinai · USVirginia Commonwealth University · US

Funding

Mapping genes that contribute to bipolar disorderZIAMH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$31.2M
Identification of Genes Involved in Major Mood DisordersZIAMH002843 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$24.5M
A Haplotype Map for Multiple SclerosisR01NS049477 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAUSER, STEPHEN L · 2005 to 2014
$15.3M
A genome-wide association study of schizophrenia in IrelandR01MH083094 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI RILEY, BRIEN P · 2008 to 2011
$3.5M
Polygenicity, Pleiotrophy and Power: Novel Statistical Methods for Gene DiscoveryR01GM104400 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THOMPSON, WESLEY KURT · 2014 to 2017
$1.6M
Medical Research Council G0800509Medical Research Council G1000708Medical Research Council MR/L010305/1NIGMS NIH HHS R01 GM104400NIMH NIH HHS R01 MH083094NINDS NIH HHS R01 NS049477Wellcome TrustWellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/Z
6 · The paper itself

Abstract

Converging evidence implicates immune abnormalities in schizophrenia (SCZ), and recent genome-wide association studies (GWAS) have identified immune-related single-nucleotide polymorphisms (SNPs) associated with SCZ. Using the conditional false discovery rate (FDR) approach, we evaluated pleiotropy in SNPs associated with SCZ (n=21,856) and multiple sclerosis (MS) (n=43,879), an inflammatory, demyelinating disease of the central nervous system. Because SCZ and bipolar disorder (BD) show substantial clinical and genetic overlap, we also investigated pleiotropy between BD (n=16,731) and MS. We found significant genetic overlap between SCZ and MS and identified 21 independent loci associated with SCZ, conditioned on association with MS. This enrichment was driven by the major histocompatibility complex (MHC). Importantly, we detected the involvement of the same human leukocyte antigen (HLA) alleles in both SCZ and MS, but with an opposite directionality of effect of associated HLA alleles (that is, MS risk alleles were associated with decreased SCZ risk). In contrast, we found no genetic overlap between BD and MS. Considered together, our findings demonstrate genetic pleiotropy between SCZ and MS and suggest that the MHC signals may differentiate SCZ from BD susceptibility.

Indexed as

Bipolar DisorderFemaleFollow-Up StudiesGenetic PleiotropyGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHLA AntigensHumansMaleMultiple SclerosisPolymorphism, Single NucleotideSchizophreniaHLA Antigens

Identifiers

PMID24468824
PMCPMC4356743
OpenAlexW2064979740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.