ArticleJournal of neuroscience methods2014
Forelimb locomotor rating scale for behavioral assessment of recovery after unilateral cervical spinal cord injury in rats.
Article in Journal of neuroscience methods, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Liposome-encapsulated clodronate and COX-2 inhibitor treatment impair ventilatory recovery but improve compensatory locomotor function following cervical spinal cord injury in rats.Experimental neurology · 2026Article
- Effect of continuous Ia fibre activity suppression on hyperreflexia-related spasticity and maladaptive synaptic connections in the spinal cord after injury.Scientific reports · 2025Article
- Can minor trauma cause asymptomatic cervical spinal cord compression leading to severe cervical spinal cord injury in rats?Neuroreport · 2025Article
- Recovery of Forearm and Fine Digit Function After Chronic Spinal Cord Injury by Simultaneous Blockade of Inhibitory Matrix Chondroitin Sulfate Proteoglycan Production and the Receptor PTPσ.Journal of neurotrauma · 2023Article
- Article
- Multifaceted Benefits of GDF11 Treatment in Spinal Cord Injury: In Vitro and In Vivo Studies.International journal of molecular sciences · 2022Article
- Acute Magnetic Resonance Imaging Predictors of Chronic Motor Function and Tissue Sparing in Rat Cervical Spinal Cord Injury.Journal of neurotrauma · 2022Article
- A novel paper MAP method for rapid high resolution histological analysis.Scientific reports · 2021Article
- Utility of somatosensory and motor-evoked potentials in reflecting gross and fine motor functions after unilateral cervical spinal cord contusion injury.Neural regeneration research · 2021Article
- The spatiotemporal spread of cervical spinal cord contusion injury pathology revealed by 3D in-line phase contrast synchrotron X-ray microtomography.Experimental neurology · 2021Article
- Comparison of two modified methods of intrathecal catheterization in rats.Experimental animals · 2020Article
- Review
- Validation of locomotion scoring as a new and inexpensive technique to record circadian locomotor activity in large mammals.Heliyon · 2018Article
- Development of the Finnish neurological function testing battery for dogs and its intra- and inter-rater reliability.Acta veterinaria Scandinavica · 2018Article
- Chronic, complete cervicalJournal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Translational Challenges of Rat Models of Upper Extremity Dysfunction After Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2018Review
- Local delivery of minocycline from metal ion-assisted self-assembled complexes promotes neuroprotection and functional recovery after spinal cord injury.Biomaterials · 2017Article
- Delayed Exercise Is Ineffective at Reversing Aberrant Nociceptive Afferent Plasticity or Neuropathic Pain After Spinal Cord Injury in Rats.Neurorehabilitation and neural repair · 2016Article
- Neural precursor cell transplantation enhances functional recovery and reduces astrogliosis in bilateral compressive/contusive cervical spinal cord injury.Stem cells translational medicine · 2014Article
- CatWalk XT Enables Sensitive Detection of Locomotor Deficits after C2 Hemisection and Integrates Readily into Ongoing Experimental Workflows in Adult Female Rats.Neurotrauma reportsArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundCervical spinal cord injury (SCI) models in rats have become increasingly useful because of their translational potential. The goal of this study was to design, develop and validate a quick and reliable forelimb locomotor rating scale for adult rats with unilateral cervical SCI injury. NEW
methodAdult female rats were subjected to a C5 unilateral mild contusion (n=10), moderate contusion (n=10) or hemisection injury (n=9). Forelimb locomotion was evaluated before injury, four times during the first week (Days 2, 3, 4 and 7) and weekly for up to 8 weeks post-injury. Scoring categories were identified and animals were ranked based on their performance in these categories. The scale was validated for its usefulness by comparing animals with different injury models (dorsolateral funiculotomy C3/4), levels of injury (moderate contusion C4) and sex (male - moderate contusion C3/4) and also by correlating FLS scores with other established behavioral tests (grid walking and kinetic tests). RESULTS AND COMPARISON WITH EXISTING
methodsForelimb performance on both the grid-walking and kinetic tests was positively correlated with the forelimb locomotor rating scale (FLS). Histological analysis established a positive correlation between the spared tissue and the observed FLS score. Our results show that the new rating scale can reliably detect forelimb deficits and recovery predicted by other behavioral tests. Furthermore, the new method provides reproducible data between trained and naïve examiners.
conclusionIn summary, the proposed rating scale is a useful tool for assessment of injury and treatments designed to enhance recovery after unilateral cervical SCI.
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