ArticleAtherosclerosis2014
Flow patterns regulate hyperglycemia-induced subendothelial matrix remodeling during early atherogenesis.
Article in Atherosclerosis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- A randomised study of the impact of the SGLT2 inhibitor dapagliflozin on microvascular and macrovascular circulation.Cardiovascular diabetology · 2017 · on this mapTrial
- The impact of a high fat diet and platelet activation on pre-metastatic niche formation.Nature communications · 2025Article
- Stratified analysis of carotid plaque and intima-media thickness as stroke predictors in type 2 diabetes.Frontiers in endocrinology · 2025Article
- EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake.Circulation research · 2024Article
- The regulation and functions of the matricellular CCN proteins induced by shear stress.Journal of cell communication and signaling · 2023Review
- Novel therapies for diabetic retinopathy.Central-European journal of immunology · 2022Review
- Paracrine Shear-Stress-Dependent Signaling from Endothelial Cells Affects Downstream Endothelial Function and Inflammation.International journal of molecular sciences · 2021Article
- Integrin affinity modulation critically regulates atherogenic endothelial activation in vitro and in vivo.Matrix biology : journal of the International Society for Matrix Biology · 2021Article
- Shear-Regulated Extracellular Microenvironments and Endothelial Cell Surface Integrin Receptors Intertwine in Atherosclerosis.Frontiers in cell and developmental biology · 2021Review
- Low shear stress induces endothelial cell apoptosis and monocyte adhesion by upregulating PECAM‑1 expression.Molecular medicine reports · 2020Article
- The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy.Journal of diabetes research · 2020 · on this mapReview
- Endothelial FN (Fibronectin) Deposition by α5β1 Integrins Drives Atherogenic Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1.Circulation · 2017Article
- EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis.Circulation · 2017Article
- Integrin signaling in atherosclerosis.Cellular and molecular life sciences : CMLS · 2017Review
- Haemodynamics Regulate Fibronectin Assembly via PECAM.Scientific reports · 2017Article
- Lack of Fibronectin Extra Domain A Alternative Splicing Exacerbates Endothelial Dysfunction in Diabetes.Scientific reports · 2016Article
- Blood Brothers: Hemodynamics and Cell-Matrix Interactions in Endothelial Function.Antioxidants & redox signaling · 2016Review
- Endothelial Mechanosignaling: Does One Sensor Fit All?Antioxidants & redox signaling · 2016Review
- The arterial microenvironment: the where and why of atherosclerosis.The Biochemical journal · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAltered subendothelial matrix composition regulates endothelial dysfunction and early atherosclerotic plaque formation. Hyperglycemia promotes endothelial matrix remodeling associated with multiple microvascular complications of diabetes, but a role for altered matrix composition in diabetic atherogenesis has not been described. Therefore, we sought to characterize the alterations in matrix composition during diabetic atherogenesis using both in vitro and in vivo model systems. METHODS AND
resultsStreptozotocin-induced diabetes in atherosclerosis-prone ApoE knockout mice promoted transitional matrix expression (fibronectin, thrombospondin-1) and deposition in intima of the aortic arch as determined by qRT-PCR array and immunohistochemistry. Early plaque formation occurs at discrete vascular sites exposed to disturbed blood flow patterns, whereas regions exposed to laminar flow are protected. Consistent with this pattern, hyperglycemia-induced transitional matrix deposition was restricted to regions of disturbed blood flow. Laminar flow significantly blunted high glucose-induced fibronectin expression (mRNA and protein) and fibronectin fibrillogenesis in endothelial cell culture models, whereas high glucose-induced fibronectin deposition was similar between disturbed flow and static conditions.
conclusionsTaken together, these data demonstrate that flow patterns and hyperglycemia coordinately regulate subendothelial fibronectin deposition during early atherogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.