Evidence map›Paper›PMID 24468022›Full record

ArticlePsychological medicine2014

Behavioral and emotional dysregulation trajectories marked by prefrontal-amygdala function in symptomatic youth.

M A Bertocci, G Bebko, T Olino, J Fournier, A K Hinze, L Bonar, J R C Almeida, S B Perlman, A Versace, M Travis and 16 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 9 institutions in 1 country.

M A BertocciDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
G BebkoDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
T OlinoDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
J FournierDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
A K HinzeDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
L BonarDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
J R C AlmeidaDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
S B PerlmanDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
A VersaceDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
M TravisDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
M K GillDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
C DemeterUniversity Hospitals Case Medical Center/Case Western Reserve University,Cleveland, OH,USA.
V A DiwadkarDepartment of Psychiatry and Behavioral Neuroscience,Wayne State University,Detroit, MI,USA.
R WhiteDepartment of Psychiatry and Behavioral Neuroscience,Wayne State University,Detroit, MI,USA.
C SchirdaDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
J L SunshineUniversity Hospitals Case Medical Center/Case Western Reserve University,Cleveland, OH,USA.
L E ArnoldDepartment of Psychiatry,Ohio State University,Columbus, OH,USA.
S K HollandCincinnati Children's Hospital Medical Center,University of Cincinnati,Cincinnati, OH,USA.
R A KowatchThe Research Institute at Nationwide Children's Hospital,Columbus, OH,USA.
B BirmaherDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
D AxelsonDepartment of Psychiatry,Ohio State University,Columbus, OH,USA.
E A YoungstromDepartment of Psychology,University of North Carolina at Chapel Hill,Chapel Hill, NC,USA.
R L FindlingUniversity Hospitals Case Medical Center/Case Western Reserve University,Cleveland, OH,USA.
S M HorwitzDepartment of Child Psychiatry,New York University School of Medicine,New York, NY,USA.
M A FristadDepartment of Psychiatry,Ohio State University,Columbus, OH,USA.
M L PhillipsDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center,University of Pittsburgh,Pittsburgh, PA,USA.
University of Pittsburgh Medical Center · USThe Ohio State University · USCase Western Reserve University · USWayne State University · USCincinnati Children's Hospital Medical Center · USJohns Hopkins University · USNationwide Children's Hospital · USNew York University · USUniversity of North Carolina at Chapel Hill · US

Funding

Longitudinal Assessment of Manic SymptomsR01MH073967 · NIMH · JOHNS HOPKINS UNIVERSITY · PI FINDLING, ROBERT L · 2005 to 2016
$11.4M
CLINICAL RESEARCH TRAINING IN CHILD PSYCHIATRYT32MH018951 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TINA R GOLDSTEIN · 1990 to 2026
$9.7M
Longitudinal Assessment of Manic Symptoms (LAMS)R01MH073953 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS, PHILLIPS, MARY LOUISE · 2005 to 2016
$8.7M
Research Methods CoreP30MH090322 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOAGWOOD, KIMBERLY E. · 2011 to 2015
$8.1M
Longitudinal Assessment of Manic Symptoms (LAMS)R01MH073816 · NIMH · CINCINNATI CHILDRENS HOSP MED CTR · PI HOLLAND, SCOTT K. · 2005 to 2016
$5.9M
Longitudinal Assessment of Manic Symptoms (LAMS) StudyR01MH073801 · NIMH · OHIO STATE UNIVERSITY · PI FRISTAD, MARY A · 2005 to 2016
$5.9M
Neural Markers of Individual Difference in Emotion Regulation in Depressed AdultsK23MH097889 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOURNIER, JAY C · 2013 to 2017
$786k
Reward-related Brain Functioning as an Endophenotype for DepressionK01MH092603 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OLINO, THOMAS M · 2011 to 2015
$701k
NIMH NIH HHS 2R01 MH73953-06A1NIMH NIH HHS K01 MH092603NIMH NIH HHS K23 MH097889NIMH NIH HHS P30 MH090322NIMH NIH HHS R01 MH073801NIMH NIH HHS R01 MH073816NIMH NIH HHS R01 MH073953NIMH NIH HHS R01 MH073967
6 · The paper itself

Abstract

backgroundNeuroimaging measures of behavioral and emotional dysregulation can yield biomarkers denoting developmental trajectories of psychiatric pathology in youth. We aimed to identify functional abnormalities in emotion regulation (ER) neural circuitry associated with different behavioral and emotional dysregulation trajectories using latent class growth analysis (LCGA) and neuroimaging.

methodA total of 61 youth (9-17 years) from the Longitudinal Assessment of Manic Symptoms study, and 24 healthy control youth, completed an emotional face n-back ER task during scanning. LCGA was performed on 12 biannual reports completed over 5 years of the Parent General Behavior Inventory 10-Item Mania Scale (PGBI-10M), a parental report of the child's difficulty regulating positive mood and energy.

resultsThere were two latent classes of PGBI-10M trajectories: high and decreasing (HighD; n=22) and low and decreasing (LowD; n=39) course of behavioral and emotional dysregulation over the 12 time points. Task performance was >89% in all youth, but more accurate in healthy controls and LowD versus HighD (p<0.001). During ER, LowD had greater activity than HighD and healthy controls in the dorsolateral prefrontal cortex, a key ER region, and greater functional connectivity than HighD between the amygdala and ventrolateral prefrontal cortex (p's<0.001, corrected).

conclusionsPatterns of function in lateral prefrontal cortical-amygdala circuitry in youth denote the severity of the developmental trajectory of behavioral and emotional dysregulation over time, and may be biological targets to guide differential treatment and novel treatment development for different levels of behavioral and emotional dysregulation in youth.

Indexed as

AdolescentAdolescent DevelopmentAffective SymptomsAmygdalaBehavioral SymptomsChildFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMalePrefrontal Cortex

Identifiers

PMID24468022
PMCPMC4344801
OpenAlexW2115749423

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.