ArticleBrain pathology (Zurich, Switzerland)2014
IgG4 overexpression is rare in meningiomas with a prominent inflammatory component: a review of 16 cases.
Article in Brain pathology (Zurich, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Proptosis Revealing a Neurological Form of IgG4-Related Disease: A Case Report and Literature Review.Cureus · 2026Article
- Angiomatous meningioma associated with rapidly aggravated peritumoral leptomeningitis: A case report.Surgical neurology international · 2023Article
- Benign Spinal Tumors.Advances in experimental medicine and biology · 2023Article
- IgG4-related hypertrophic pachymeningitis with tumor-like intracranial and intracerebral lesions.Acta neurochirurgica · 2022Article
- Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression.Autopsy & case reports · 2022Article
- A rare cystic lymphoplasmacyte-rich meningioma: A case report and review of the literature.Surgical neurology international · 2020Article
- Large dural-based mass with bony hyperostosis in a 16-year-old male: IgG4-related disease mimicking lymphoplasmacyte-rich meningioma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- IgG4-related intracranial disease.The neuroradiology journal · 2019Article
- Severe headache in a patient with meningioma showing extensive dural tail correlates with IgG4-positive plasma cells and eosinophils: A case report and review of literature.Surgical neurology international · 2018Article
- Pathology and molecular genetics of meningioma: recent advances.Neurologia medico-chirurgica · 2015Review
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7 authors at 6 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Meningiomas with prominent inflammation are traditionally classified as "lymphoplasmacyte-rich meningioma" (LPM). Both inflammatory and neoplastic meningeal proliferations have recently been linked to IgG4 disease, although a potential association with LPM has not been previously explored. Sixteen meningiomas with inflammatory cells outnumbering tumor cells were further characterized by CD3, CD20, CD68 and/or CD163, CD138, kappa, lambda, IgG and IgG4 immunostains. There were 11 female and 4 male patients, ranging from 22 to 78 (median 59) years of age. Tumors consisted of 10 World Health Organization (WHO) grade I, 5 grade II and 1 grade III LPMs. Immunohistochemically, the most numerous cell type was the macrophage in all cases followed by CD3-positive T cells and fewer CD20-positive B cells. Plasma cells ranged from moderate-marked (N = 5) to rare (N = 7), or absent (N = 4). Maximal numbers of IgG4 plasma cells per high power field (HPF) ranged from 0 to 32, with only two cases having counts exceeding 10/HPF. The IgG4/IgG ratio was increased focally in only two cases (30% and 31%). Additionally, plasma cells represented only a minor component in most examples, whereas macrophages predominated, suggesting that "inflammation-rich meningioma" may be a more accurate term. The inflammatory stimulus for most cases remains to be elucidated.
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