Evidence map›Paper›PMID 24466502›Full record

ArticleCurrent nutrition reports2013

Dietary Cholesterol and Plasma Lipoprotein Profiles: Randomized-Controlled Trials.

John D Griffin, Alice H Lichtenstein

Open access · bronzeAbstract read
In one paragraph

Article in Current nutrition reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. MoSMikrochimica acta · 2026
    Article
  8. Article
  9. Hepatic cholesterol biosynthesis and dioxin-induced dysregulation: A multiscale computational approach.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023
    Article
  10. Article
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  14. Review
  15. Article
  16. Effect ofSaudi journal of biological sciences · 2019
    Article
  17. Article
  18. Review
  19. Article
  20. Whole egg consumption and cortical bone in healthy children.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John D GriffinTufts University, JM USDA Human Nutrition Research Center on Aging, 711 Washington Street, Boston, MA 02111, John.Griffin@Tufts.edu.
Alice H LichtensteinTufts University, JM USDA Human Nutrition Research Center on Aging, 711 Washington Street, Boston, MA 02111, phone: 617 556 3127, Alice.Lichtenstein@Tufts.edu.
Tufts University · US

Funding

Research Training Program in Nutrition, Obesity and Metabolic DisordersT32DK062032 · NIDDK · TUFTS UNIVERSITY BOSTON · PI GREENBERG, ANDREW S · 2002 to 2016
$2.6M
Cholesterol Homeostasis in Framingham Offspring StudyR01HL074388 · NHLBI · TUFTS UNIVERSITY BOSTON · PI LICHTENSTEIN, ALICE H · 2003 to 2006
$772k
NHLBI NIH HHS R01 HL074388NIDDK NIH HHS T32 DK062032
6 · The paper itself

Abstract

Early work suggested that dietary cholesterol increases plasma total cholesterol concentrations in humans. Given the relationship between elevated plasma cholesterol concentrations and cardiovascular disease risk dietary guidelines have consistently recommended limiting food sources of cholesterol. Current intakes are approaching recommended levels. Recently there have been calls to reassess the importance of continuing to recommend limiting dietary cholesterol. Over the past 10 years there have been a limited number of studies addressing this issue. Striking among these studies is the high degree of variability in background diet, subject characteristics and study design. Within the context of current levels of dietary cholesterol intake, the effect on plasma lipids concentrations, with primary interest in LDL-C cholesterol concentrations, is modest and appears to be limited to population subgroups. In these cases, restrictions in dietary cholesterol intake are likely warranted. The biological determinants of inter-individual variability remain a relatively understudied area.

Indexed as

Cardiovascular diseaseCholesterol absorptionDietary cholesterolEggsHigh density lipoprotein cholesterolLow density lipoprotein cholesterolPlasma cholesterolTotal cholesterol:high density lipoprotein cholesterol ratio

Identifiers

PMID24466502
PMCPMC3900007
OpenAlexW1996116130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.