ArticleBiomedical optics express2013
Tethered confocal endomicroscopy capsule for diagnosis and monitoring of eosinophilic esophagitis.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Endoscope Capsules: The Present Situation and Future Outlooks.Bioengineering (Basel, Switzerland) · 2023Review
- Intravital longitudinal cellular visualization of oral mucosa in a murine model based on rotatory side-view confocal endomicroscopy.Biomedical optics express · 2022Article
- Pediatric eosinophilic esophagitis: a review for the clinician.Italian journal of pediatrics · 2021Review
- Review
- Novel Insights Into Tissue-Specific Biochemical Alterations in Pediatric Eosinophilic Esophagitis Using Raman Spectroscopy.Clinical and translational gastroenterology · 2020Observational
- Diagnosis and treatment of eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2020Review
- One-Hour Esophageal String Test: A Nonendoscopic Minimally Invasive Test That Accurately Detects Disease Activity in Eosinophilic Esophagitis.The American journal of gastroenterology · 2019Article
- A miniaturized, tethered, spectrally-encoded confocal endomicroscopy capsule.Lasers in surgery and medicine · 2019Article
- Eosinophilic Esophagitis.The Medical clinics of North America · 2019Review
- Clinical Translation of Tethered Confocal Microscopy Capsule for Unsedated Diagnosis of Eosinophilic Esophagitis.Scientific reports · 2018Article
- Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiographyOptica · 2018Article
- Unsedated In-office Transgastrostomy Esophagoscopy to Monitor Therapy in Pediatric Esophageal Disease.Journal of pediatric gastroenterology and nutrition · 2018Article
- Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction.Nature reviews. Gastroenterology & hepatology · 2017Review
- Unsedated transnasal esophagoscopy for monitoring therapy in pediatric eosinophilic esophagitis.Gastrointestinal endoscopy · 2016Article
- Eosinophilic esophagitis: search for noninvasive techniques for long-term monitoring.Gastrointestinal endoscopy · 2016Article
- Optical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diode.Scientific reports · 2015Article
- Ultrahigh speed en face OCT capsule for endoscopic imaging.Biomedical optics express · 2015Article
- A pulse coupled neural network segmentation algorithm for reflectance confocal images of epithelial tissue.PloS one · 2015Article
- Miniature objective lens with variable focus for confocal endomicroscopy.Biomedical optics express · 2014Article
- Advances in clinical management of eosinophilic esophagitis.Gastroenterology · 2014Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Eosinophilic esophagitis (EoE) is an allergic condition that is characterized by eosinophils infiltrating the esophageal wall. The treatment of the disease may require multiple follow up sedated endoscopies and biopsies to confirm elimination of eosinophils. These procedures are expensive, time consuming, and may be difficult for patients to tolerate. Here we report on the development of a confocal microscopy capsule for diagnosis and monitoring of EoE. The swallowable capsule implements a high-speed fiber-based reflectance confocal microscopy technique termed Spectrally Encoded Confocal Microscopy (SECM). SECM scans the sample in one dimension without moving parts by using wavelength swept source illumination and a diffraction grating at the back plane of the objective lens. As the wavelength of the source is tuned, the SECM optics within the 7 x 30 mm capsule are rotated using a driveshaft enclosed in a 0.8 mm flexible tether. A single rotation of the optics covered a field of view of 22 mm x 223 µm. The lateral and axial resolutions of the device were measured to be 2.1 and 14 µm, respectively. Images of Acetic Acid stained swine esophagus obtained with the capsule ex vivo and in vivo clearly showed squamous epithelial nuclei, which are smaller and less reflective than eosinophils. Imaging of esophageal biopsies from EoE patients ex vivo demonstrated the capability of this technology to visualize individual eosinophils. Based on the results of this study, we believe that this capsule will be a simpler and more effective device for diagnosing EoE and monitoring the therapeutic response of this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.