Evidence map›Paper›PMID 24466486›Full record

ArticleBiomedical optics express2013

Toward nodal staging of axillary lymph node basins through intradermal administration of fluorescent imaging agents.

Funda Meric-Bernstam, John C Rasmussen, Savitri Krishnamurthy, I-Chih Tan, Banghe Zhu, Jamie L Wagner, Gildy V Babiera, Elizabeth A Mittendorf, Eva M Sevick-Muraca

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
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  9. Emerging lymphatic imaging technologies for mouse and man.The Journal of clinical investigation · 2014
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Funda Meric-BernstamDepartment of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA ; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA ; These authors contributed equally to this work.
John C RasmussenCenter for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine at the University of Texas Health Science Center at Houston, Houston, TX 77030 USA ; These authors contributed equally to this work.
Savitri KrishnamurthyDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.
I-Chih TanCenter for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine at the University of Texas Health Science Center at Houston, Houston, TX 77030 USA.
Banghe ZhuCenter for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine at the University of Texas Health Science Center at Houston, Houston, TX 77030 USA.
Jamie L WagnerDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.
Gildy V BabieraDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.
Elizabeth A MittendorfDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.
Eva M Sevick-MuracaCenter for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine at the University of Texas Health Science Center at Houston, Houston, TX 77030 USA.
The University of Texas MD Anderson Cancer Center · USThe University of Texas Health Science Center at Houston · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kathrin Milbury · 1985 to 2026
$290.8M
U OF TEXAS HLTH SCI CTR HOUSTON CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCESUL1RR024148 · NCRR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2006 to 2010
$27.9M
Task Specific Project 4U54CA136404 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SEVICK, EVA M. · 2008 to 2012
$5.1M
NCI NIH HHS P30 CA016672NCI NIH HHS U54 CA136404NCRR NIH HHS UL1 RR024148
6 · The paper itself

Abstract

As part of a proof-of-concept study for future delivery of targeted near-infrared fluorescent (NIRF) tracers, we sought to assess the delivery of micrograms of indocyanine green to all the axillary lymph nodes following intraparenchymal breast injections and intradermal arm injections in 20 subjects with advanced breast carcinoma and undergoing complete axillary lymph node dissection. Lymphatic vessels and nodes were assessed in vivo. Ex vivo images demonstrated that 87% of excised lymph nodes, including 81% of tumor-positive lymph nodes, were fluorescent. Future clinical studies using microdose amounts of tumor-targeting NIRF contrast agents may demonstrate improved surgical intervention with reduced morbidity.

Indexed as

(100.2960) Image analysis(170.0110) Imaging systems(170.1610) Clinical applications(170.3880) Medical and biological imaging

Identifiers

PMID24466486
PMCPMC3891331
OpenAlexW1976291855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.