ArticleBiomedical optics express2013
Label-free multimodal nonlinear optical microscopy reveals fundamental insights of skeletal muscle development.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Inspiring a convergent engineering approach to measure and model the tissue microenvironment.Heliyon · 2024Review
- Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during skeletal muscle regeneration.Science advances · 2023Article
- Monitoring the macrophage response towards biomaterial implants using label-free imaging.Materials today. Bio · 2023Article
- Label-free multimodal nonlinear optical microscopy reveals features of bone composition in pathophysiological conditions.Frontiers in bioengineering and biotechnology · 2022Article
- Rapid pseudo-H&E imaging using a fluorescence-inbuilt optical coherence microscopic imaging system.Biomedical optics express · 2021Article
- In Vivo nonlinear optical imaging of immune responses: tissue injury and infection.Biophysical journal · 2014Article
- Biological imaging with coherent Raman scattering microscopy: a tutorial.Journal of biomedical optics · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
We developed a label-free nonlinear optical (NLO) microscope integrating the stimulated Raman scattering, multi-color two-photon excited fluorescence and second harmonic generation. The system produces multimodal images of protein content, mitochondria distribution and sarcomere structure of fresh muscle samples. With the advanced imaging technique, we studied the mal-development of skeletal muscle caused by sarcomeric gene deficiency. In addition, important development processes of normal muscle from neonatal to adult stage were also clearly revealed based on the changing sarcomere structure, mitochondria distribution and muscle fiber size. The results demonstrate that the newly developed multimodal NLO microscope is a powerful tool to assess the muscle integrity and function.
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Registered trials
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