ArticleBiomedical optics express2013
Towards clinically translatable NIR fluorescence molecular guidance for colonoscopy.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Compact dual-channel visible-light fluorescence endoscope for real-time molecular imaging: system design and validation in ectopic pregnancy tissue.Biomedical optics express · 2026Article
- Multi-contrast laser endoscopy for in vivo gastrointestinal imaging.Npj imaging · 2026Article
- A novel flexible near-infrared endoscopic device that enables real-time artificial intelligence fluorescence tissue characterization.PloS one · 2025Article
- Convolutional neural network advances in demosaicing for fluorescent cancer imaging with color-near-infrared sensors.Journal of biomedical optics · 2024Article
- Detection of Tumour-Targeted IRDye800CW Tracer with Commercially Available Laparoscopic Surgical Systems.Diagnostics (Basel, Switzerland) · 2023Article
- Standardization and implementation of fluorescence molecular endoscopy in the clinic.Journal of biomedical optics · 2022Article
- Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal Cancer.Frontiers in oncology · 2022Review
- Use of Fluorescent Dyes in Endoscopy and Diagnostic Investigation.Visceral medicine · 2020Review
- A roadmap for the clinical implementation of optical-imaging biomarkers.Nature biomedical engineering · 2019Review
- Bimodal reflectance and fluorescence multispectral endoscopy based on spectrally resolving detector arrays.Journal of biomedical optics · 2018Article
- Perspective review of what is needed for molecular-specific fluorescence-guided surgery.Journal of biomedical optics · 2018Review
- Molecular fluorescence-guided surgery of peritoneal carcinomatosis of colorectal origin: A narrative review.Journal of surgical oncology · 2018Review
- Potential Red-Flag Identification of Colorectal Adenomas with Wide-Field Fluorescence Molecular Endoscopy.Theranostics · 2018Article
- Intravital imaging of mouse colonic adenoma using MMP-based molecular probes with multi-channel fluorescence endoscopy.Biomedical optics express · 2014Article
- Introduction: feature issue on optical molecular probes, imaging, and drug delivery.Biomedical optics express · 2014Article
- Target-to-background enhancement in multispectral endoscopy with background autofluorescence mitigation for quantitative molecular imaging.Journal of biomedical optics · 2014Article
- Research Progress of Autofluorescence Imaging Technology in the Diagnosis of Early Gastrointestinal Tumors.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White-light surveillance colonoscopy is the standard of care for the detection and removal of premalignant lesions to prevent colorectal cancer, and the main screening recommendation following treatment for recurrence detection. However, it lacks sufficient diagnostic yield, exhibits unacceptable adenoma miss-rates and is not capable of revealing functional and morphological information of the detected lesions. Fluorescence molecular guidance in the near-infrared (NIR) is expected to have outstanding relevance regarding early lesion detection and heterogeneity characterization within and among lesions in these interventional procedures. Thereby, superficial and sub-surface tissue biomarkers can be optimally visualized due to a minimization of tissue attenuation and autofluorescence by comparison with the visible, which simultaneously enhance tissue penetration and assure minimal background. At present, this potential is challenged by the difficulty associated with the clinical propagation of disease-specific contrast agents and the absence of a commercially available endoscope that is capable of acquiring wide-field, NIR fluorescence at video-rates. We propose two alternative flexible endoscopic fluorescence imaging methods, each based on a CE certified commercial, clinical grade endoscope, and the employment of an approved monoclonal antibody labeled with a clinically applicable NIR fluorophore. Pre-clinical validation of these two strategies that aim at bridging NIR fluorescence molecular guidance to clinical translation is demonstrated in this study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.