ArticleBiomedical optics express2013
High-resolution visualization of mouse cardiac microvasculature using optical histology.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- In vitro vascularization improves in vivo functionality of human engineered cardiac tissues.Acta biomaterialia · 2026Article
- Semi-automated protocol to quantify and characterize fluorescent three-dimensional vascular images.PloS one · 2024Article
- Simple methodology to visualize whole-brain microvasculature in three dimensions.Neurophotonics · 2021Article
- Optical clearing potential of immersion-based agents applied to thick mouse brain sections.PloS one · 2019Article
- Looking inside the heart: a see-through view of the vascular tree.Biomedical optics express · 2017Article
- Light-sheet fluorescence imaging to localize cardiac lineage and protein distribution.Scientific reports · 2017Article
- Deep tissue imaging: a review from a preclinical cancer research perspective.Histochemistry and cell biology · 2016Review
- 3D imaging in CUBIC-cleared mouse heart tissue: going deeper.Biomedical optics express · 2016Article
- Visualization of microbleeds with optical histology in mouse model of cerebral amyloid angiopathy.Microvascular research · 2016Article
- Optical clearing based cellular-level 3D visualization of intact lymph node cortex.Biomedical optics express · 2015Article
- Optical properties of mouse brain tissue after optical clearing with FocusClear™.Journal of biomedical optics · 2015Article
- Optical clearing in dense connective tissues to visualize cellular connectivity in situ.PloS one · 2015Article
- Advances in optics for biotechnology, medicine and surgery.Biomedical optics express · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cardiovascular disease typically is associated with dysfunction of the coronary vasculature and microvasculature. The study of cardiovascular disease typically involves imaging of the large coronary vessels and quantification of cardiac blood perfusion. These methods, however, are not well suited for imaging of the cardiac microvasculature. We used the optical histology method, which combines chemical optical clearing and optical imaging, to create high-resolution, wide-field maps of the cardiac microvasculature in ventral slices of mouse heart. We have demonstrated the ability of the optical histology method to enable wide-field visualization of the cardiac microvasculature in high-resolution and anticipate that optical histology may have significant impact in studying cardiovascular disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.