ReviewBoneKEy reports2014
Vitamin D: calcium and bone homeostasis during evolution.
Review in BoneKEy reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it, 183 citations in OpenAlex.
- Easy to gain but hard to lose: the evolution of the knee sesamoid bones in Primates-a systematic review and phylogenetic meta-analysis.Proceedings. Biological sciences · 2024Pooled it
- Trying to identify who may benefit most from future vitamin D intervention trials: a post hoc analysis from the VITDAL-ICU study excluding the early deaths.Critical care (London, England) · 2019Trial
- Characterization of a CYP107 family vitamin DArchives of biochemistry and biophysics · 2026Article
- Dietary Intake of 25-Hydroxy Vitamin D3 from First Feeding Improves Feed Efficiency and Modulates Hepatic Metabolic Transcriptome in Rainbow Trout.Marine biotechnology (New York, N.Y.) · 2026Article
- Establishment and evaluation of hematological and serum biochemical reference intervals in Chinese local donkey populations.BMC veterinary research · 2026Article
- Vesicles for cell crosstalk in bone: composition, function and application.Science China. Life sciences · 2026Review
- From Sunlight to Signaling: Evolutionary Integration of Vitamin D and Sterol Metabolism.Metabolites · 2026Review
- Article
- Sunlight Sonata: Contrasting the Roles of Solar Ultraviolet Radiation and Temperature on the Calling Behavior of a Diurnal Forest-specialist Frog.Zoological studies · 2026Article
- The Causal Relationship Between Zinc and Osteoarthritis: A Two-Sample Mendelian Randomization Study.Biological trace element research · 2025Article
- Larval Pigmentation Reveals Environmental and Genetic Influences in Hybridizing Ambystoma Salamanders.Ecology and evolution · 2025Article
- Interaction between the non-alcoholic fatty liver disease fibrosis score and vitamin D deficiency on left ventricular hypertrophy and impaired diastolic function in patients with type 2 diabetes mellitus.Diabetology & metabolic syndrome · 2025Article
- Circadian Regulation of Vitamin D Target Genes Reveals a Network Shaped by Individual Responsiveness.Nutrients · 2025Article
- The pathology of vitamin D3 deficiency in the growing Najdi lambs.Brazilian journal of veterinary medicine · 2025Article
- EarlyFrontiers in immunology · 2025Article
- Review
- Unveiling the Metabolic Trajectory of Pig Feces Across Different Ages and Senescence.Metabolites · 2024Article
- Vitamin D and Aging: Central Role of Immunocompetence.Nutrients · 2024Review
- Health Effects of Vitamin D Supplementation: Lessons Learned From Randomized Controlled Trials and Mendelian Randomization Studies.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Review
- Vitamin DGeroScience · 2023Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D3 is already found early in the evolution of life but essentially as inactive end products of the photochemical reaction of 7-dehydrocholestol with ultraviolet light B. A full vitamin D (refers to vitamin D2 and D3) endocrine system, characterized by a specific VDR (vitamin D receptor, member of the nuclear receptor family), specific vitamin D metabolizing CYP450 enzymes regulated by calciotropic hormones and a dedicated plasma transport-protein is only found in vertebrates. In the earliest vertebrates (lamprey), vitamin D metabolism and VDR may well have originated from a duplication of a common PRX/VDR ancestor gene as part of a xenobiotic detoxification pathway. The vitamin D endocrine system, however, subsequently became an important regulator of calcium supply for an extensive calcified skeleton. Vitamin D is essential for normal calcium and bone homeostasis as shown by rickets in vitamin D-deficient growing amphibians, reptiles, birds and mammals. From amphibians onward, bone is gradually more dynamic with regulated bone resorption, mainly by combined action of PTH and 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the generation and function of multinucleated osteoclasts. Therefore, bone functions as a large internal calcium reservoir, under the control of osteoclasts. Osteocytes also display a remarkable spectrum of activities, including mechanical sensing and regulating mineral homeostasis, but also have an important role in global nutritional and energy homeostasis. Mineralization from reptiles onward is under the control of well-regulated SIBLING proteins and associated enzymes, nearly all under the control of 1,25(OH)2D3. The vitamin D story thus started as inert molecule but gained an essential role for calcium and bone homeostasis in terrestrial animals to cope with the challenge of higher gravity and calcium-poor environment.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.