Evidence map›Paper›PMID 24466331›Full record

ArticlePloS one2014

Pre- and neonatal exposure to lipopolysaccharide or the enteric metabolite, propionic acid, alters development and behavior in adolescent rats in a sexually dimorphic manner.

Kelly A Foley, Klaus-Peter Ossenkopp, Martin Kavaliers, Derrick F Macfabe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 126 citations in OpenAlex.

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  19. Neuromotor Development in theBrain sciences · 2022
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kelly A FoleyGraduate Program in Neuroscience, The University of Western Ontario, London, Ontario, Canada ; Department of Psychology, The University of Western Ontario, London, Ontario, Canada.
Klaus-Peter OssenkoppGraduate Program in Neuroscience, The University of Western Ontario, London, Ontario, Canada ; Department of Psychology, The University of Western Ontario, London, Ontario, Canada ; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, The University of Western Ontario, London, Ontario, Canada.
Martin KavaliersGraduate Program in Neuroscience, The University of Western Ontario, London, Ontario, Canada ; Department of Psychology, The University of Western Ontario, London, Ontario, Canada ; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, The University of Western Ontario, London, Ontario, Canada.
Derrick F MacfabeDepartment of Psychology, The University of Western Ontario, London, Ontario, Canada ; The Kilee Patchell-Evans Autism Research Group, Division of Developmental Disabilities, Departments of Psychology and Psychiatry, The University of Western Ontario, London, Ontario, Canada.
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in the composition of the gut microbiome and/or immune system function may have a role in the development of autism spectrum disorders (ASD). The current study examined the effects of prenatal and early life administration of lipopolysaccharide (LPS), a bacterial mimetic, and the short chain fatty acid, propionic acid (PPA), a metabolic fermentation product of enteric bacteria, on developmental milestones, locomotor activity, and anxiety-like behavior in adolescent male and female offspring. Pregnant Long-Evans rats were subcutaneously injected once a day with PPA (500 mg/kg) on gestation days G12-16, LPS (50 µg/kg) on G15-16, or vehicle control on G12-16 or G15-16. Male and female offspring were injected with PPA (500 mg/kg) or vehicle twice a day, every second day from postnatal days (P) 10-18. Physical milestones and reflexes were monitored in early life with prenatal PPA and LPS inducing delays in eye opening. Locomotor activity and anxiety were assessed in adolescence (P40-42) in the elevated plus maze (EPM) and open-field. Prenatal and postnatal treatments altered behavior in a sex-specific manner. Prenatal PPA decreased time spent in the centre of the open-field in males and females while prenatal and postnatal PPA increased anxiety behavior on the EPM in female rats. Prenatal LPS did not significantly influence those behaviors. Evidence for the double hit hypothesis was seen as females receiving a double hit of PPA (prenatal and postnatal) displayed increased repetitive behavior in the open-field. These results provide evidence for the hypothesis that by-products of enteric bacteria metabolism such as PPA may contribute to ASD, altering development and behavior in adolescent rats similar to that observed in ASD and other neurodevelopmental disorders.

Indexed as

Sex CharacteristicsAnimalsAnxietyBehavior, AnimalChild Development Disorders, PervasiveEnterobacteriaceaeFemaleGrowth and DevelopmentLinear ModelsLipopolysaccharidesLocomotionMaleMaze LearningPregnancyPrenatal Exposure Delayed EffectsPropionatesLipopolysaccharidesPropionatespropionic acid

Identifiers

PMID24466331
PMCPMC3899377
OpenAlexW2155900825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.