ArticlePloS one2014
Comparative analysis of αB-crystallin expression in heat-stressed myocardial cells in vivo and in vitro.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Chronic heat stress induces the expression ofFrontiers in genetics · 2023Article
- Modulation of Heat-Shock Proteins Mediates Chicken Cell Survival against Thermal Stress.Animals : an open access journal from MDPI · 2020Review
- Article
- A monoclonal antibody targeted to the functional peptide of αB-crystallin inhibits the chaperone and anti-apoptotic activities.Journal of immunological methods · 2019Article
- Heat stress-induced renal damage in poultry and the protective effects of HSP60 and HSP47.Cell stress & chaperones · 2018Article
- Differential Glycosylation and Modulation of Camel and Human HSP Isoforms in Response to Thermal and Hypoxic Stresses.International journal of molecular sciences · 2018Article
- Rosemary Reduces Heat Stress by Inducing CRYAB and HSP70 Expression in Broiler Chickens.Oxidative medicine and cellular longevity · 2018Article
- Aspirin upregulates αB-Crystallin to protect the myocardium against heat stress in broiler chickens.Scientific reports · 2016Article
- Aspirin-induced heat stress resistance in chicken myocardial cells can be suppressed by BAPTA-AM in vitro.Cell stress & chaperones · 2016Article
- Cytoprotective effect of palm kernel cake phenolics against aflatoxin B1-induced cell damage and its underlying mechanism of action.BMC complementary and alternative medicine · 2015Article
- Heat shock proteins: a therapeutic target worth to consider.Veterinary world · 2015Review
- Palm kernel cake extract exerts hepatoprotective activity in heat-induced oxidative stress in chicken hepatocytes.BMC complementary and alternative medicine · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Relationships between αB-crystallin expression patterns and pathological changes of myocardial cells after heat stress were examined in vitro and in vivo in this study using the H9C2 cell line and Sprague-Dawley rats, respectively. Histopathological lesions, characterized by acute degeneration, karyopyknosis and loss of a defined nucleus, became more severe in rat hearts over the course of heat stress treatment from 20 min to 100 min. The expression of αB-crystallin in rat hearts showed a significant decrease (P<0.05) throughout the heat stress treatment period, except at the 40 min time point. Likewise, decreased αB-crystallin expression was also observed in the H9C2 cell line exposed to a high temperature in vitro, although its expression recovered to normal levels at later time points (80 and 100 min) and the cellular damage was less severe. The results suggest that αB-crystallin is mobilized early after exposure to a high temperature to interact with damaged proteins but that the myocardial cells cannot produce sufficient αB-crystallin for protection against heat stress. Lower αB-crystallin expression levels were accompanied by obvious cell/tissue damage, suggesting that the abundance of this protein is associated with protective effects in myocardial cells in vitro and in vivo. Thus, αB-crystallin is a potential biomarker of heat stress.
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