ArticlePloS one2014
Use of the delta neutrophil index as a prognostic factor of mortality in patients with spontaneous bacterial peritonitis: implications of a simple and useful marker.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- The delta neutrophil index (DNI) as a prognostic marker for mortality in adults with sepsis: a systematic review and meta-analysis.Scientific reports · 2018Pooled it
- Delta neutrophil index (DNI) as a novel diagnostic and prognostic marker of infection: a systematic review and meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Pooled it
- The Role of the Delta Neutrophil Index in Determining the Severity of Intrahepatic Cholestasis of Pregnancy.Saudi medical journal · 2026Article
- A nomogram model based on routine serum markers for predicting the occurrence of primary cholangitis after Kasai operation for biliary atresia.Translational pediatrics · 2025Article
- Delta neutrophil index in obese and non-obese polycystic ovary syndrome patients.Obstetrics & gynecology science · 2023Article
- Delta Neutrophil Index for the Prediction of Prognosis in Acute Gastrointestinal Diseases; Diagnostic Test Accuracy Meta-Analysis.Journal of clinical medicine · 2020Article
- Delta neutrophil index for predicting mortality in trauma patients who underwent emergent abdominal surgery: A case controlled study.PloS one · 2020Article
- Delta neutrophil index as a prognostic marker in emergent abdominal surgery.Journal of clinical laboratory analysis · 2019Article
- Bacterascites: A study of clinical features, microbiological findings, and clinical significance.Liver international : official journal of the International Association for the Study of the Liver · 2018Article
- Which patients with intestinal obstruction need surgery? The delta neutrophil index as an early predictive marker.Annals of surgical treatment and research · 2017Article
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- Presepsin teardown - pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis.World journal of gastroenterology · 2016Article
- The usefulness of serum delta neutrophil index for differentiating bacterial and viral meningitis in the emergency department.Clinical and experimental emergency medicine · 2016Article
- Delta neutrophil index as a promising prognostic marker in out of hospital cardiac arrest.PloS one · 2015Article
- Delta neutrophil index as a prognostic marker of early mortality in gram negative bacteremia.Infection & chemotherapy · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpontaneous bacterial peritonitis (SBP) is a common and life-threatening infection in patients with advanced cirrhosis. The prognostic value of a novel marker, the delta neutrophil index (DNI), was investigated relative to mortality in patients with SBP. MATERIALS &
methodsSeventy-five patients with SBP were studied from April 2010 to May 2012. DNI at initial diagnosis of SBP was determined and compared with 30-day mortality rates.
resultsOf the patients, 87.7% were men, and the median age of all patients was 59.0 yrs. The area under the receiver-operating characteristic (ROC) curve of DNI for 30-day mortality was 0.701 (95% confidence interval [CI], 0.553-0.849; p = 0.009), which was higher than that of C-reactive protein (0.640, 95% CI, 0.494-0.786; p = 0.076) or the model for end-stage liver disease score (0.592, 95% CI, 0.436-0.748; p = 0.235). From the ROC curve, with the sum of sensitivity and specificity, the cutoff value of DNI was determined to be 5.7%. In the high-DNI group (DNI ≥5.7%), septic shock and 30-day mortality were more prevalent compared with the low-DNI group (84.2% vs. 48.2%, p = 0.007; 57.9% vs. 14.3%, p<0.001, respectively). Patients with an elevated DNI had a higher risk of 30-day mortality compared with those with a low DNI (4.225, 95% CI, 1.631-10.949; p = 0.003).
conclusionA higher DNI at the time of SBP diagnosis is an independent predictor of 30-day mortality in patients with SBP.
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