ArticlePloS one2014
A chromosomal region on ECA13 is associated with maxillary prognathism in horses.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Clinical findings of candidate stallions presented for licensing at all German Warmblood horse-breeding associations in 2018-2020.Equine veterinary journal · 2025Article
- Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era.Animal genetics · 2019Review
- Orthodontics and Genetics.Dental press journal of orthodontics · 2019Article
- Treatment of class 2 malocclusion by corrective osteotomy using two short locking compression plates.Equine veterinary journal · 2019Article
- Cephalometric Study of the Overjet Development in Warmblood Foals.Frontiers in veterinary science · 2019Article
- An integrated genomic approach for the study of mandibular prognathism in the European seabass (Dicentrarchus labrax).Scientific reports · 2016Article
- Imputation of sequence level genotypes in the Franches-Montagnes horse breed.Genetics, selection, evolution : GSE · 2014Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hereditary variations in head morphology and head malformations are known in many species. The most common variation encountered in horses is maxillary prognathism. Prognathism and brachygnathism are syndromes of the upper and lower jaw, respectively. The resulting malocclusion can negatively affect teeth wear, and is considered a non-desirable trait in breeding programs. We performed a case-control analysis for maxillary prognathism in horses using 96 cases and 763 controls. All horses had been previously genotyped with a commercially available 50 k SNP array. We analyzed the data with a mixed-model considering the genomic relationships in order to account for population stratification. Two SNPs within a region on the distal end of chromosome ECA 13 reached the Bonferroni corrected genome-wide significance level. There is no known prognathism candidate gene located within this region. Therefore, our findings in the horse offer the possibility of identifying a novel gene involved in the complex genetics of prognathism that might also be relevant for humans and other livestock species.
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