ArticlePloS one2014
Porphyromonas gingivalis infection reduces regulatory T cells in infected atherosclerosis patients.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Longitudinal relationship between atherosclerosis and progression of periodontitis in community-dwelling people in Nagasaki Islands Study.Scientific reports · 2025Article
- The Oral-Gut-Brain Axis: The Influence of Microbes as a Link of Periodontitis With Ischemic Stroke.CNS neuroscience & therapeutics · 2024Review
- Balancing the Oral-Gut-Brain Axis with Diet.Nutrients · 2024Review
- Association between periodontal disease and coronary heart disease: A bibliometric analysis.Heliyon · 2024Article
- RhoA/ROCK1 regulates the mitochondrial dysfunction through Drp1 induced by Porphyromonas gingivalis in endothelial cells.Journal of cellular and molecular medicine · 2023Article
- Article
- The Composition of Subgingival Microbiome in Hidradenitis Suppurativa and Periodontitis Patients.Pathogens (Basel, Switzerland) · 2023Article
- Porphyromonas gingivalis infection promotes inflammation via inhibition of the AhR signalling pathway in periodontitis.Cell proliferation · 2023Article
- Review
- Article
- Association betweenFrontiers in cellular and infection microbiology · 2022Review
- The Effects ofFrontiers in immunology · 2021Review
- Metabolic Disturbance and Th17/Treg Imbalance Are Associated With Progression of Gingivitis.Frontiers in immunology · 2021Observational
- Mesenchymal Stromal/Stem Cells-Derived Exosomes as an Antimicrobial Weapon for Orodental Infections.Frontiers in microbiology · 2021Review
- Review
- Cross-Sectional Analysis of the Association between Periodontitis and Cardiovascular Disease Using the Korean Genome and Epidemiology Study Data.International journal of environmental research and public health · 2020Article
- Periodontitis and cardiovascular diseases: Consensus report.Journal of clinical periodontology · 2020Review
- Periodontitis and Cardiovascular Diseases. Consensus Report.Global heart · 2020Review
- Roles of Porphyromonas gingivalis and its virulence factors in periodontitis.Advances in protein chemistry and structural biology · 2020Review
- Potential of iPSC-Derived Mesenchymal Stromal Cells for Treating Periodontal Disease.Stem cells international · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence has shown periodontal pathogen Porphyromonas gingivalis (P.gingivalis) infection contributes to atherosclerosis (AS) progression. P.gingivalis fimbriae act as an important virulence factor in AS. Regulatory T cells (Tregs) may play a crucial role in autoimmune response during this process. However, whether P.gingivalis infection is associated with Tregs dysregulation during AS is still unknown and the prevalence of different P.gingivalis FimA genotypes during this process is unclear. Here we analyzed the distribution of Tregs and in P.gingivalis-infected atherosclerotic patients to reveal the relationship between P.gingivalis infection and Tregs reduction/dysfunction and to elucidate their role in periodontitis-AS interaction. FimA genotype was also examined to determine the prevalence of fimbriae. Our results showed that P.gingivalis infection reduced Tregs in atherosclerotic patients compared with non-atherosclerotic patients and health controls. Concentration of TGF-β1, which plays an important role in the development of Tregs, also decreased in P.gingivalis infected patients. Furthermore, type II FimA seems to show higher prevalence than the other five detected types. The population of Tregs further decreased in patients with type II FimA compared with the other types. P.gingivlias FimA genotype II was the dominant type associated with decreased Treg population. These results indicate that P.gingivalis infection may be associated with Tregs dysregulation in AS; type II FimA may be a predominant genotype in this process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.