ArticlePloS one2014
Plasma D-dimer levels are associated with stroke subtypes and infarction volume in patients with acute ischemic stroke.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- A Systematic Review of the Predictive Value of Plasma D-Dimer Levels for Predicting Stroke Outcome.Frontiers in neurology · 2021Pooled it
- Prognostic Hemostasis Biomarkers in Acute Ischemic Stroke.Arteriosclerosis, thrombosis, and vascular biology · 2019Pooled it
- Therapeutic Potential of Lumbrokinase in Acute Ischemic Stroke: A Meta-Analysis of Efficacy and Safety.Therapeutics and clinical risk management · 2025Review
- D-Dimer Levels and NIHSS as Prognostic Predictors in Elderly Patients with Cerebral Infarction.Clinical interventions in aging · 2025Article
- Clinical significance of D-dimer levels during acute period in ischemic stroke.Thrombosis journal · 2023Article
- d-Dimer Level After Endovascular Treatment Can Help Predict Outcome of Acute Ischemic Stroke.Stroke (Hoboken, N.J.) · 2023Article
- Retraction: Plasma D-Dimer Levels Are Associated with Stroke Subtypes and Infarction Volume in Patients with Acute Ischemic Stroke.PloS one · 2022Article
- Retraction: The Relationship between Serum Insulin-Like Growth Factor I Levels and Ischemic Stroke Risk.PloS one · 2022Article
- Retraction: Cortisol as a Prognostic Marker of Short-Term Outcome in Chinese Patients with Acute Ischemic Stroke.PloS one · 2022Article
- Retraction: Insulin-Like Growth Factor-1 as a Prognostic Marker in Patients with Acute Ischemic Stroke.PloS one · 2022Article
- Retraction: Plasma D-Dimer Predicts Short-Term Poor Outcome after Acute Ischemic Stroke.PloS one · 2022Article
- COVID-19-associated ischaemic stroke despite use of anticoagulation.BMJ case reports · 2021Article
- Quantitatively monitoring acute ischemic stroke patients post recombinant tissue plasminogen activator treatment.Health science reports · 2021Article
- D-dimer Level is Correlated with Prognosis, Infarct Size, and NIHSS in Acute Ischemic Stroke PatientsIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Pre-Therapeutic Factors Predicting for the Necessity of Rescue Treatments in Mechanical Thrombectomy.Journal of neuroendovascular therapy · 2021Article
- Decompressive hemicraniectomy for acute ischemic stroke associated with coronavirus disease 2019 infection: Case report and systematic review.Surgical neurology international · 2021Article
- Promising Biomarker Candidates for Cardioembolic Stroke Etiology. A Brief Narrative Review and Current Opinion.Frontiers in neurology · 2021Review
- Blood-Based Biomarkers Are Associated with Different Ischemic Stroke Mechanisms and Enable Rapid Classification between Cardioembolic and Atherosclerosis Etiologies.Diagnostics (Basel, Switzerland) · 2020Review
- Arterial and venous strokes in the setting of COVID-19.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2020Article
- Prediction of deep vein thrombosis by ultrasonography and D-dimer in Asian patients with ischemic stroke.BMC neurology · 2020Article
Corrections and comments
- Retraction · 2022-03-30Concerns/Issues about Data · Duplication of/in Article · Paper Mill ·
- Retracted
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been suggested that modestly elevated circulating D-dimer values may be associated with acute ischemic stroke (AIS). Thus, the purpose of this study was to investigate the association between plasma D-dimer level at admission and AIS in Chinese population.
methodsIn a prospective observational study, plasma D-dimer levels were measured using a particle-enhanced, immunoturbidimetric assay on admission in 240 Chinese patients with AIS. The National Institutes of Health Stroke Scale (NIHSS) score was assessed on admission blinded to D-dimer levels.
resultsPlasma median D-dimer levels were significantly (P = 0.000) higher in AIS patients as compared to healthy controls (0.88; interquartiler range [IQR], 0.28-2.11 mg/L and 0.31; IQR, 0.17-0.74 mg/L). D-dimer levels increased with increasing severity of stroke as defined by the NIHSS score(r = 0.179, p = 0.005) and infarct volume(r = 0.425, p = 0.000). Those positive trends still existed even after correcting for possible confounding factors (P = 0.012, 0.000; respectively). Based on the Receiver operating characteristic (ROC) curve, the optimal cut-off value of plasma D-dimer levels as an indicator for diagnosis of cardioembolic strokes was projected to be 0.91 mg/L, which yielded a sensitivity of 83.7% and a specificity of 81.5%, the area under the curve was 0.862(95% confidence interval [CI], 0.811-0.912).
conclusionWe had shown that plasma D-dimer levels increased with increasing severity of stroke as defined by the NIHSS score and infarct volume. These associations were independent other possible variables. In addition, cardioembolic strokes can be distinguished from other stroke etiologies by measuring plasma D-dimer levels very early (0-48 hours from stroke symptom onset).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.